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gene 1,034 words KG: EED
Contents

EED

🧬 Gene Info
Gene SymbolEED
Full NameEmbryonic Ectoderm Development
Chromosome11q14.2
Functionencodes a core scaffolding subunit of Polycomb Repressive Complex 2 (PRC2), the multisubunit complex responsible for trimethylation of histone H3 at lysine 27 (H3K27me3).
PathwaysMapk, Microrna, Nf-Kb, Wnt
UniProt IDO75530
Ensembl IDENSG00000074266
OMIM605984
GeneCardsEED
Human Protein AtlasEED
Associated Diseasesneurodegeneration
InteractionsActin, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, Aβ, COMPLEMENT
KG Connections125 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64Glycosaminoglycan Template Disruption Approach
Score: 0.60TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (4)

Astrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archivedProtein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40AAV-LRRK2 Gene Therapy IND-Enabling Study Design
clinical · proposed · Score: 0.40Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40Pre-Symptomatic Tau Detection in MAPT Mutation Carriers
clinical · proposed · Score: 0.40Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_withABI3 Gene
gene · KG edge: associated_withACE Gene
gene · KG edge: associated_withadam17
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TNF regulates EED
PI3K regulates EED
EZH2 interacts_with EED
BCL2 regulates EED
GSK3B regulates EED
AKT regulates EED
EED regulates CTNNB1
APOE co_discussed EED
APP co_discussed EED
BIN1 co_discussed EED

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