gene

il17a

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about il17a: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

1Analyses

14Outgoing

6Incoming

0Experiments

1Debates

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🧬 Gene Info

Gene Symbol	IL17A
Full Name	Interleukin 17A
Chromosome	6p12.2.
Function	is a 155-amino acid secreted glycoprotein that forms disulfide-linked homodimers.
Primary Expression	non-immune cells including neurons and glia
Amino Acids	155 aa
Pathways	NF-κB pathway, MAPK pathway, TGF-β
UniProt ID	[Q16552](https://www.uniprot.org/uniprot/Q16552)
Ensembl ID	ENSG00000112116
OMIM	603250
GeneCards	IL17A
Human Protein Atlas	IL17A
IL17RC	co-receptor, especially highly expressed in non-immune cells including neurons and glia
NF-κB pathway	Classical pro-inflammatory signaling via IKK complex activation
MAPK pathways	C/EBPβ, C/EBPδ, and AP-1 family transcription factors
Associated Diseases	Senescence
Known Drugs/Compounds	hyperforin
Interactions	BMAL1, DNMT1, PARKIN, TNF
KG Connections	20 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL17A — Interleukin 17A

gene · 753 words

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Pathway Diagram

graph TD
    IL17A["IL17A"]
    IL17A -->|"inhibits"| PARKIN["PARKIN"]
    IL17A -->|"promotes"| mitochondrial_dysfunction["mitochondrial dysfunction"]
    IL17A -->|"involved_in"| Staphylococcus_Aureus_Infectio["Staphylococcus Aureus Infection"]
    IL17A -->|"inhibits"| BMAL1["BMAL1"]
    IL17A -->|"activates"| DNMT1["DNMT1"]
    IL17A -->|"implicated in"| neurodegeneration["neurodegeneration"]
    hyperforin["hyperforin"] -->|"inhibits"| IL17A

Outgoing (14)

Target	Relation	Type	Str
PARKIN	inhibits	gene	0.90
myeloid cell immune response	mediates	process	0.90
mitochondrial dysfunction	promotes	phenotype	0.90
Staphylococcus Aureus Infection	involved_in	disease	0.85
Staphylococcus Aureus Infection	mediates	disease	0.85
BMAL1	inhibits	protein	0.70
DNMT1	activates	protein	0.70
Senescence	associated_with	disease	0.65
CFH	associated_with	gene	0.60
Epigenetic	associated_with	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
TNF	activates	gene	0.60
IL3	associated_with	gene	0.60
IL9	associated_with	gene	0.60

Incoming (6)

Source	Relation	Type	Str
hyperforin	inhibits	drug	0.80
IL10	associated_with	gene	0.60
TP53	associated_with	gene	0.60
APOE	associated_with	gene	0.60
IL6	associated_with	gene	0.60
H4	associated_with	hypothesis	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 5 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

Related Research

Hypotheses and analyses mentioning il17a in their description or question text

No additional research found