Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHKA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
No AI portrait yet
| Name | CHKA |
| Key Genes/Proteins | AKT, CEBPB, DNMT1, EGF, EGFR, ERCC3 |
| Related Diseases | Hepatic Steatosis, translational_neuroscience |
| Related Pathways | PI3K-AKT-mTOR signaling |
graph TD
CHKA[CHKA]
CHKA -->|suppresses| Hepatic_Steatosis[Hepatic Steatosis]
CHKA -->|activates| EGF[EGF]
CHKA -->|activates| EGFR[EGFR]
CHKA -->|activates| ERCC3[ERCC3]
CHKA -->|activates| PDK1[PDK1]
CHKA -->|activates| PI3K[PI3K]
CHKA -->|activates| SMPD1[SMPD1]
CHKA -->|participates in| PI3K_AKT_mTOR_signaling[PI3K-AKT-mTOR signaling]
CHKA -->|expressed in| neurons[neurons]
CHKA -->|data_in| benchmark_ot_ad_answer_key_CHK[benchmark_ot_ad_answer_key:CHKA]
DNMT1[DNMT1] -->|downregulates| CHKA
AKT[AKT] -->|activates| CHKA
CEBPB[CEBPB] -->|activates| CHKA
h_5b0ebb1f[h-5b0ebb1f] -->|targets| CHKA
benchmark_ot_ad_answer_key_CHK -->|data_in| CHKA| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:CHKA | data_in | dataset_row | 0.00 |
| Hepatic Steatosis | suppresses | disease | 0.90 |
| SMPD1 | activates | gene | 0.60 |
| EGF | activates | gene | 0.60 |
| EGFR | activates | gene | 0.60 |
| ERCC3 | activates | gene | 0.60 |
| PDK1 | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| translational_neuroscience | associated_with | disease | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:CHKA | data_in | dataset_row | 0.00 |
| DNMT1 | downregulates | protein | 0.90 |
| AKT | activates | gene | 0.60 |
| CEBPB | activates | gene | 0.60 |
| h-5b0ebb1f | targets | hypothesis | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Choline Kinase Activity as Membrane Integrity Response Indic | 0.663 | translational neuroscience | Which metabolic biomarkers can distingui |
Scientific analyses that reference this entity
translational neuroscience | 2026-04-04 | 7 hypotheses Top: 0.819
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity