concept

CHKA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHKA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections
1Hypotheses
1Analyses
11Outgoing
5Incoming
0Experiments
1Debates

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💡 Concept Info
NameCHKA
Key Genes/ProteinsAKT, CEBPB, DNMT1, EGF, EGFR, ERCC3
Related DiseasesHepatic Steatosis, translational_neuroscience
Related PathwaysPI3K-AKT-mTOR signaling

Pathway Diagram

graph TD
    CHKA[CHKA]
    CHKA -->|suppresses| Hepatic_Steatosis[Hepatic Steatosis]
    CHKA -->|activates| EGF[EGF]
    CHKA -->|activates| EGFR[EGFR]
    CHKA -->|activates| ERCC3[ERCC3]
    CHKA -->|activates| PDK1[PDK1]
    CHKA -->|activates| PI3K[PI3K]
    CHKA -->|activates| SMPD1[SMPD1]
    CHKA -->|participates in| PI3K_AKT_mTOR_signaling[PI3K-AKT-mTOR signaling]
    CHKA -->|expressed in| neurons[neurons]
    CHKA -->|data_in| benchmark_ot_ad_answer_key_CHK[benchmark_ot_ad_answer_key:CHKA]
    DNMT1[DNMT1] -->|downregulates| CHKA
    AKT[AKT] -->|activates| CHKA
    CEBPB[CEBPB] -->|activates| CHKA
    h_5b0ebb1f[h-5b0ebb1f] -->|targets| CHKA
    benchmark_ot_ad_answer_key_CHK -->|data_in| CHKA

Outgoing (11)

TargetRelationTypeStr
benchmark_ot_ad_answer_key:CHKAdata_indataset_row0.00
Hepatic Steatosissuppressesdisease0.90
SMPD1activatesgene0.60
EGFactivatesgene0.60
EGFRactivatesgene0.60

Incoming (5)

SourceRelationTypeStr
benchmark_ot_ad_answer_key:CHKAdata_indataset_row0.00
DNMT1downregulatesprotein0.90
AKTactivatesgene0.60
CEBPBactivatesgene0.60
h-5b0ebb1ftargetshypothesis0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Choline Kinase Activity as Membrane Integrity Response Indic 0.663 translational neuroscience Which metabolic biomarkers can distingui

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

translational neuroscience | 2026-04-04 | 7 hypotheses Top: 0.819

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

closed · Rounds: 4 · Score: 0.92 · 2026-04-04