SciDEX — CHLOROQUINE

graph TD
    CHLOROQUINE["CHLOROQUINE"]
    CHLOROQUINE -->|"modulates"| Tumor_Associated_Macrophages["Tumor-Associated Macrophages"]
    CHLOROQUINE -->|"modulates"| Antitumor_Immune_Response["Antitumor Immune Response"]
    CHLOROQUINE -->|"inhibits"| mitophagy["mitophagy"]
    CHLOROQUINE -->|"inhibits"| Autophagy["Autophagy"]
    CHLOROQUINE -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    CHLOROQUINE -->|"activates"| CTSD["CTSD"]
    CHLOROQUINE -->|"regulates"| IMMUNE_RESPONSE["IMMUNE RESPONSE"]
    CANCER["CANCER"] -->|"regulates"| CHLOROQUINE

Outgoing (84)

Target	Relation	Type	Str
Tumor-Associated Macrophages	modulates	cell_type	0.95
Antitumor Immune Response	modulates	process	0.90
M1 Phenotype	associated_with	phenotype	0.90
mitophagy	inhibits	pathway	0.85
Autophagy	inhibits	process	0.75
MAP1LC3B	regulates	protein	0.70
IMMUNE RESPONSE	regulates	phenotype	0.65
CTSD	activates	gene	0.65
CASP3	associated_with	gene	0.50
GLUT4	associated_with	gene	0.50
CTSB	associated_with	gene	0.50
TSC2	associated_with	gene	0.50
SLC2A4	associated_with	gene	0.50
ATG16L1	associated_with	gene	0.50
PINK1	associated_with	gene	0.50
OPTN	associated_with	gene	0.50
PTEN	associated_with	gene	0.50
ATM	associated_with	gene	0.50
MTOR	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
AKT	associated_with	gene	0.45
CHOLESTEROL	associated_with	phenotype	0.45
SQSTM1	associated_with	gene	0.45
ABCA1	associated_with	gene	0.45
AMPK	associated_with	gene	0.45
ATG5	associated_with	gene	0.45
ULK1	associated_with	gene	0.45
ALS	associated_with	disease	0.45
LAMP2	associated_with	gene	0.45
MACROPHAGES	associated_with	cell_type	0.45
UBIQUITIN	associated_with	protein	0.45
MELANOMA	associated_with	disease	0.45
NLRP3	associated_with	gene	0.45
CASP1	associated_with	gene	0.45
LAMP1	associated_with	gene	0.45
IL1B	associated_with	gene	0.45
TNF	associated_with	gene	0.45
BECN1	associated_with	gene	0.45
HIF1A	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
RAPAMYCIN	associated_with	drug	0.45
CANCER	associated_with	disease	0.45
HUNTINGTIN	associated_with	protein	0.45
DEMENTIA	associated_with	disease	0.45
NEURON	associated_with	cell_type	0.45
DNMT1	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
ATG7	associated_with	gene	0.45
GABA	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45

Incoming (29)

Source	Relation	Type	Str
CANCER	regulates	disease	0.65
ATORVASTATIN	associated_with	drug	0.45
GLIOBLASTOMA	associated_with	disease	0.45
HYDROXYCHLOROQUINE	associated_with	drug	0.45
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
DNA DAMAGE RESPONSE	associated_with	pathway	0.45
DOPAMINERGIC NEURONS	associated_with	cell_type	0.45
SUBSTANTIA NIGRA	associated_with	brain_region	0.45
IMMUNE RESPONSE	associated_with	phenotype	0.45
AKT	associated_with	gene	0.45
APOE	associated_with	gene	0.45
AUTOPHAGY	associated_with	phenotype	0.45
ABCA1	associated_with	gene	0.45
ALS	associated_with	disease	0.45
AMPK	associated_with	gene	0.45
ATG5	associated_with	gene	0.45
ATP	associated_with	phenotype	0.45
CASP1	associated_with	gene	0.45
BBB	associated_with	phenotype	0.45
BECN1	associated_with	gene	0.45
CANCER	associated_with	disease	0.45
ATG7	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
BCL2	associated_with	gene	0.45
AUTOPHAGOSOMES	associated_with	organelle	0.45
SPINAL MUSCULAR ATROPHY	associated_with	disease	0.45
ATHEROSCLEROSIS	associated_with	disease	0.45
GLIAL FIBRILLARY ACIDIC PROTEIN	associated_with	biomarker	0.45

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Name	CHLOROQUINE
Key Genes/Proteins	ABCA1, ABCG1, AKT, AMPK, APOE, ATG12
Related Diseases	ALS, AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS, ATHEROSCLEROSIS

CHLOROQUINE

Understanding Entity Pages

Pathway Diagram

Outgoing (84)

Incoming (29)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

Related Research