concept

AUTOPHAGOSOMES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AUTOPHAGOSOMES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections

0Hypotheses

1Analyses

50Outgoing

17Incoming

0Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	AUTOPHAGOSOMES
Key Genes/Proteins	ABCA1, ABCG1, AMPK, APOE, ATG5, ATG7
Related Diseases	AGING, ALS, APOPTOSIS, ATHEROSCLEROSIS, AUTOPHAGY

Pathway Diagram

graph TD
    AUTOPHAGOSOMES[AUTOPHAGOSOMES]
    AUTOPHAGOSOMES -->|interacts| Lysosomes[Lysosomes]
    AUTOPHAGOSOMES -->|inhibits| MTOR[MTOR]
    AUTOPHAGOSOMES -->|regulates| AUTOPHAGY[AUTOPHAGY]
    AUTOPHAGOSOMES -->|activates| FIBROBLASTS[FIBROBLASTS]
    AUTOPHAGOSOMES -->|stabilizes| TUMOR_CELLS[TUMOR CELLS]
    AUTOPHAGOSOMES -->|inhibits| VCP[VCP]
    SQSTM1[SQSTM1] -->|targets| AUTOPHAGOSOMES
    DNC1[DNC1] -->|regulates| AUTOPHAGOSOMES
    TBK1[TBK1] -->|modifies| AUTOPHAGOSOMES
    AMPK[AMPK] -->|activates| AUTOPHAGOSOMES
    GLIOBLASTOMA[GLIOBLASTOMA] -->|regulates| AUTOPHAGOSOMES
    AUTOPHAGY -->|activates| AUTOPHAGOSOMES
    P62_SQSTM1[P62_SQSTM1] -->|regulates| AUTOPHAGOSOMES
    MTOR -->|exacerbates| AUTOPHAGOSOMES
    TAU[TAU] -->|phosphorylates| AUTOPHAGOSOMES

Outgoing (56)

Target	Relation	Type	Str
Lysosomes	interacts_with	organelle	0.90
Lysosomes	associated_with	cell_type	0.85
AUTOPHAGY	regulates	phenotype	0.65
MTOR	inhibits	gene	0.65
MTOR	regulates	gene	0.65
FIBROBLASTS	regulates	cell_type	0.65
FIBROBLASTS	activates	cell_type	0.65
TUMOR CELLS	stabilizes	cell_type	0.65
VCP	inhibits	gene	0.60
FIBROBLASTS	expressed_in	cell_type	0.55
VCP	associated_with	gene	0.50
TUMOR CELLS	associated_with	cell_type	0.50
RAPAMYCIN	associated_with	drug	0.50
AGING	associated_with	phenotype	0.50
presynaptic_terminals	accumulate_at	mechanism	0.50
TAU	associated_with	protein	0.50
TFEB	associated_with	gene	0.50
PARKIN	associated_with	gene	0.50
PINK1	associated_with	gene	0.50
DRP1	associated_with	gene	0.50
LAMP1	associated_with	gene	0.50
APOE	associated_with	gene	0.50
ABCA1	associated_with	gene	0.45
P2RY12	associated_with	gene	0.45
SQSTM1	associated_with	gene	0.45
ULK1	associated_with	gene	0.45
LAMP2	associated_with	gene	0.45
ATG5	associated_with	gene	0.45
ABCG1	associated_with	gene	0.45
FIBROBLASTS	associated_with	cell_type	0.45
NEURON	associated_with	cell_type	0.45
ROS	associated_with	phenotype	0.45
ATORVASTATIN	associated_with	drug	0.45
CHLOROQUINE	associated_with	drug	0.45
CHOLESTEROL	associated_with	phenotype	0.45
AUTOPHAGY	associated_with	phenotype	0.45
AMPK	associated_with	gene	0.45
ALS	associated_with	disease	0.45
MITOPHAGY	associated_with	phenotype	0.45
BECN1	associated_with	gene	0.45
MTOR	associated_with	gene	0.45
ATG7	associated_with	gene	0.45
C9orf72	associated_with	gene	0.45
TBK1	associated_with	gene	0.45
CGAS	associated_with	gene	0.45
UBIQUITIN	associated_with	protein	0.45
IL6	associated_with	gene	0.45
FERROPTOSIS	associated_with	phenotype	0.45
CELL DEATH	associated_with	phenotype	0.45
TUMOR GROWTH	associated_with	phenotype	0.45

Incoming (17)

Source	Relation	Type	Str
SQSTM1	targets	gene	0.90
DNC1	regulates	gene	0.80
AMPK	activates	gene	0.65
GLIOBLASTOMA	regulates	disease	0.65
AUTOPHAGY	activates	phenotype	0.65
AUTOPHAGY	degrades	phenotype	0.65
TBK1	modifies	gene	0.65
P62_SQSTM1	regulates	protein	0.64
MTOR	exacerbates	gene	0.60
TAU	phosphorylates	protein	0.60
TAU	regulates	protein	0.60
MITOPHAGY	interacts_with	phenotype	0.60
UBIQUITIN	implicated_in	protein	0.55
AUTOPHAGY	implicated_in	phenotype	0.55
BAG3	recruits_Hsc70_clients_to	gene	0.50
LYSOSOMAL DYSFUNCTION	associated_with	phenotype	0.50
ATHEROSCLEROSIS	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 7 hypotheses Top: 0.533

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning AUTOPHAGOSOMES in their description or question text

No additional research found