gene

SLC2A4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC2A4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

15Outgoing

32Incoming

0Experiments

0Debates

Summary

Solute Carrier Family 2 Member 4 (GLUT4) gene

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🧬 Gene Info

Gene Symbol	SLC2A4
Aliases	GLUT4
Chromosome	17q21.1
Protein Type	Gene
Function	SLC2A4 encodes GLUT4, an insulin-responsive glucose transporter.
Primary Expression	certain brain regions and may play a role in hypothalamic glucose sensing
Ensembl ID	ENSG00000181856
GeneCards	SLC2A4
Human Protein Atlas	SLC2A4
Associated Diseases	multiple sclerosis
Known Drugs/Compounds	rapamycin
Interactions	AMPK, ATG5, ATM, ATR, CASP3, CTSB
KG Connections	47 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SLC2A4 Gene

gene · 684 words

→

SLC2A4RG Protein (SLC2A4 Regulator)

protein · 1948 words

→

Pathway Diagram

graph TD
    ASPSCR1["ASPSCR1"]
    SLC2A4["SLC2A4
(GLUT4)"]
    GlucoseUptake["Glucose Uptake"]
    InsulinSignaling["Insulin Signaling"]
    PI3K_AKT["PI3K/AKT Pathway"]
    GLUT4_Translocation["GLUT4 Translocation"]
    Neuronal_Metabolism["Neuronal Glucose Metabolism"]
    Energy_Production["ATP Production"]
    Metabolic_Dysfunction["Metabolic Dysfunction"]
    Insulin_Resistance["Insulin Resistance"]
    Oxidative_Stress["Oxidative Stress"]
    Neuroinflammation["Neuroinflammation"]
    Protein_Aggregation["Protein Aggregation"]
    Synaptic_Dysfunction["Synaptic Dysfunction"]
    Neurodegeneration["Neurodegeneration"]

    ASPSCR1 -->|"regulates"| SLC2A4
    InsulinSignaling -->|"activates"| PI3K_AKT
    PI3K_AKT -->|"promotes"| GLUT4_Translocation
    GLUT4_Translocation -->|"enhances"| SLC2A4
    SLC2A4 -->|"mediates"| GlucoseUptake
    GlucoseUptake -->|"supports"| Neuronal_Metabolism
    Neuronal_Metabolism -->|"generates"| Energy_Production
    Insulin_Resistance -->|"impairs"| PI3K_AKT
    Metabolic_Dysfunction -->|"reduces"| GlucoseUptake
    Metabolic_Dysfunction -->|"promotes"| Oxidative_Stress
    Oxidative_Stress -->|"triggers"| Neuroinflammation
    Neuroinflammation -->|"induces"| Protein_Aggregation
    Protein_Aggregation -->|"causes"| Synaptic_Dysfunction
    Synaptic_Dysfunction -->|"leads to"| Neurodegeneration
    Energy_Production -->|"prevents"| Metabolic_Dysfunction

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:2px,color:#fff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff

    class SLC2A4 central
    class GlucoseUptake,Neuronal_Metabolism,Energy_Production protective
    class Metabolic_Dysfunction,Insulin_Resistance,Oxidative_Stress,Neuroinflammation,Protein_Aggregation,Synaptic_Dysfunction pathological
    class ASPSCR1,InsulinSignaling,PI3K_AKT,GLUT4_Translocation regulatory
    class Neurodegeneration disease

Outgoing (15)

Target	Relation	Type	Str
Glucose Uptake	mediates	process	0.90
TSC2	activates	gene	0.60
ULK1	activates	gene	0.60
TRPML1	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
multiple sclerosis	associated_with	disease	0.60
oligodendrocytes	expressed_in	cell_type	0.60
multiple sclerosis	inhibits	disease	0.60
pyroptosis	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
multiple sclerosis	activates	disease	0.60
neurons	expressed_in	cell_type	0.55

Incoming (32)

Source	Relation	Type	Str
ASPSCR1	regulates	gene	0.95
ATG5	activates	gene	0.60
ATM	activates	gene	0.60
ATR	activates	gene	0.60
CASP3	activates	gene	0.60
CTSB	activates	gene	0.60
CTSD	activates	gene	0.60
DYNLL1	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GAPDH	activates	gene	0.60
HOMER1	activates	gene	0.60
JNK1	activates	gene	0.60
LAMP1	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MAP2	activates	gene	0.60
MAPK14	activates	gene	0.60
MAPK8	activates	gene	0.60
MCOLN1	activates	gene	0.60
RILP	activates	gene	0.60
NLRP3	inhibits	gene	0.60
NLRP3	activates	gene	0.60
rapamycin	targets	drug	0.60
GLUT4	activates	gene	0.60
LC3B	activates	gene	0.60
GLUT4	inhibits	gene	0.60
AMPK	activates	gene	0.60
GFP	activates	gene	0.60
ROS	activates	gene	0.60
RAPAMYCIN	associated_with	drug	0.50
CHLOROQUINE	associated_with	drug	0.50
ETOPOSIDE	associated_with	drug	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLC2A4 in their description or question text

No additional research found