protein 1,183 words KG: CXCL8
Contents

CXCL8 Protein

🔬 Protein Info
Gene SymbolCXCL8
Chromosome4q13.3
Protein FamilyCXC chemokine family (ELR+)
Functionis a protein encoded by the CXCL8 gene.
Primary Expressionthe central nervous system, influencing neurotransmitter release and synaptic plasticity[@biber2002]
Subcellular LocalizationSecreted, extracellular
Molecular Weight8 kDa
Amino Acids99 aa
Exons4
PathwaysNF-κB
UniProt ID[P10145](https://www.uniprot.org/uniprot/P10145)
NCBI Gene ID3576
GeneCardsCXCL8
Human Protein AtlasCXCL8
Associated DiseasesALS, Alzheimer, Depression, Fibrosis, Inflammation, Ms
Known Drugs/Compoundsrapamycin
InteractionsActin, adcy2, ADCY2, AGING, AKT, ALZHEIMER
KG Connections493 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.55
Blood-Brain Barrier SPM Shuttle System
Score: 0.53

Related Analyses (9)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (6)

ADCY2 — Adenylate Cyclase 2
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: associated_with
ANG — Angiogenin
gene · KG edge: associated_with
BAX Gene
gene · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with

Knowledge Graph (12 edges)

IL1B regulates CXCL8
TLR2 regulates CXCL8
CXCL1 regulates CXCL8
JUN regulates CXCL8
MMP9 regulates CXCL8
TNF regulates CXCL8
CXCL8 regulates TLR2
CXCL8 regulates MMP9
CXCL8 regulates IL1B
CXCL8 regulates JUN

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