gene

IL22

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL22: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

61Connections

0Hypotheses

0Analyses

41Outgoing

20Incoming

0Experiments

0Debates

Summary

IL22 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, causes, activates. Associated with Als, Atherosclerosis, Inflammation. Connected to 19 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL22
Chromosome	12q13
Function	is a member of the IL-10 cytokine family, encoded by the IL22 gene located on chromosome 12q13 [1](https://www.
Primary Expression	the CNS: - Astrocytes: Produce IL22 in response to inflammation - Neurons: Express IL22R in some regions - Microglia: Respond to IL22 sign
Pathways	JAK-STAT pathway, MAPK pathway, PI3K
Ensembl ID	ENSG00000127353
GeneCards	IL22
Human Protein Atlas	IL22
Associated Diseases	Als
Interactions	CD4, IFNG, IL31, IL6R, INFLAMMATION, MMP12
KG Connections	61 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL22

gene · 668 words

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Pathway Diagram

graph TD
    IL22["IL22"]
    STAT3["STAT3"]
    JAK["JAK"]
    CD4["CD4+ T cells"]
    IFNG["IFN-gamma"]
    S100A8["S100A8"]
    S100A9["S100A9"]
    IL31["IL31"]
    Inflammation["Inflammation"]
    ALS["Amyotrophic Lateral Sclerosis"]
    Atherosclerosis["Atherosclerosis"]
    Differentiation["T cell Differentiation"]
    Neurodegeneration["Neurodegeneration"]
    CLDN1["CLDN1"]
    BBB["Blood-Brain Barrier"]

    STAT3 -->|"transcriptionally activates"| IL22
    IL22 -->|"activates"| JAK
    JAK -->|"phosphorylates"| STAT3
    IL22 -->|"stimulates"| CD4
    CD4 -->|"produces"| IL22
    IFNG -->|"induces expression"| IL22
    S100A8 -->|"co-expressed with"| IL22
    IL22 -->|"upregulates"| S100A9
    IL22 -->|"co-expressed with"| IL31
    IL22 -->|"promotes"| Inflammation
    IL22 -->|"contributes to"| ALS
    IL22 -->|"associated with"| Atherosclerosis
    IL22 -->|"regulates"| Differentiation
    Inflammation -->|"leads to"| Neurodegeneration
    ALS -->|"type of"| Neurodegeneration
    CLDN1 -->|"barrier function"| BBB
    IL22 -->|"affects"| CLDN1

    style IL22 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style ALS fill:#ef5350,stroke:#000,stroke-width:2px
    style Neurodegeneration fill:#ef5350,stroke:#000,stroke-width:2px
    style Inflammation fill:#ef5350,stroke:#000,stroke-width:2px
    style Atherosclerosis fill:#ef5350,stroke:#000,stroke-width:2px
    style STAT3 fill:#4a1a6b,stroke:#000,stroke-width:2px
    style JAK fill:#4a1a6b,stroke:#000,stroke-width:2px
    style IFNG fill:#4a1a6b,stroke:#000,stroke-width:2px
    style CD4 fill:#1b5e20,stroke:#000,stroke-width:2px
    style Differentiation fill:#1b5e20,stroke:#000,stroke-width:2px

Outgoing (41)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Als	causes	disease	0.65
Inflammation	activates	disease	0.65
PVALB	associated_with	gene	0.60
JAK	causes	gene	0.60
Il-1	expressed_in	protein	0.60
IL31	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
CLDN1	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60
IL6R	associated_with	gene	0.60
MMP12	associated_with	gene	0.60
IFNG	expressed_in	gene	0.60
IL6R	interacts_with	gene	0.60
MMP12	interacts_with	gene	0.60
PVALB	interacts_with	gene	0.60
Macrophage	therapeutic_target	cell_type	0.60
T Cell	therapeutic_target	cell_type	0.60
INFLAMMATION	expressed_in	gene	0.60
CD4	activates	gene	0.60
RNA	expressed_in	gene	0.60
IL4R	expressed_in	gene	0.60
IL-13	expressed_in	gene	0.60
AND	associated_with	gene	0.60
LOR	expressed_in	gene	0.60
Interleukin	expressed_in	protein	0.60
GENES	expressed_in	gene	0.60
Differentiation	expressed_in	pathway	0.60
AND	expressed_in	gene	0.60
Ca1	expressed_in	brain_region	0.55
T Cell	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55
Proteins	activates	protein	0.50
PVALB	activates	gene	0.50
MMP12	activates	gene	0.50
IL31	activates	gene	0.50
IFNG	activates	gene	0.50
CLDN1	activates	concept	0.50

Incoming (20)

Source	Relation	Type	Str
RNA	expressed_in	gene	0.60
PVALB	associated_with	gene	0.60
S100A9	expressed_in	gene	0.60
AHR	regulates	gene	0.60
STAT3	causes	gene	0.60
IL4R	expressed_in	gene	0.60
GAIN	causes	gene	0.60
GENES	expressed_in	gene	0.60
CCL26	expressed_in	gene	0.60
INFLAMMATION	activates	gene	0.60
IFNG	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60
CLDN1	expressed_in	gene	0.60
IL6R	associated_with	gene	0.60
GENES	associated_with	gene	0.60
IL-13	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
S100A8	activates	gene	0.50
S100A9	activates	gene	0.50
IL6R	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL22 in their description or question text

No additional research found