Contents

CCL2 Protein

🔬 Protein Info

Gene Symbol	CCL2
Aliases	CCL2PROTEIN
Chromosome	17q12
Primary Expression	blood-brain barrier, spinal cord, Cerebellum, Spinal Cord
Subcellular Localization	</strong> Secreted (extracellular)</div>
Molecular Weight	9.9 kDa
Amino Acids	99 aa
Pathways	NF-κB
GeneCards	CCL2
Human Protein Atlas	CCL2
Promoter elements	Contains binding sites for NF-κB, AP-1, and other transcription factors responsive to inflammatory stimuli
Tissue-specific expression	Constitutively expressed at low levels in many tissues; dramatically upregulated by pro-inflammatory cytokines
Alternative splicing	Produces multiple splice variants with potentially distinct functions
N-terminal region	Contains the receptor-binding site; critical for receptor activation
Core domain	Consists of a beta-sheet with three anti-parallel strands
Associated Diseases	Als, Alzheimer, Cancer, Chronic Obstructive Pulmonary Disease, dementia
Known Drugs/Compounds	metformin, METFORMIN
Interactions	ACHE, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK
KG Connections	954 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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