gene

CACNA2D1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA2D1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

18Outgoing

21Incoming

0Experiments

0Debates

Summary

CACNA2D1 encodes the alpha2 delta-1 subunit of voltage-gated calcium channels, essential for synaptic transmission and muscle function.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CACNA2D1
Full Name	Calcium Channel Voltage-Dependent Subunit Alpha2 Delta 1
Chromosome	7q21.11
Protein Type	Channel
Function	is a critical component of L-type and N-type calcium channels, modulating channel trafficking, gating, and synaptic localization.
Primary Expression	High in brain, skeletal muscle, heart
Amino Acids	1256 aa
UniProt ID	Q13926
NCBI Gene ID	781
Ensembl ID	ENSG00000153991
OMIM	114204
GeneCards	CACNA2D1
Human Protein Atlas	CACNA2D1
Associated Diseases	neurodegeneration
Interactions	CACNA1A, CACNA1C, CACNA1D, CACNA1E, cacna1f, CACNA1F
KG Connections	39 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CACNA2D1 — AlphaFold Q13926 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CACNA2D1 Gene - Calcium Channel Voltage-Dependent Subunit Alpha2 Delta 1

gene · 1037 words

→

Pathway Diagram

graph TD
    CACNA2D1["CACNA2D1"]
    CACNA1E["CACNA1E"]
    CACNA2D1 -->|"associated with"| CACNA1E
    CACNA1H["CACNA1H"]
    CACNA2D1 -->|"associated with"| CACNA1H
    CACNA1D["CACNA1D"]
    CACNA2D1 -->|"associated with"| CACNA1D
    CACNA1G["CACNA1G"]
    CACNA2D1 -->|"associated with"| CACNA1G
    GAIN["GAIN"]
    CACNA2D1 -->|"contributes to"| GAIN
    CACNA1F["CACNA1F"]
    CACNA2D1 -->|"associated with"| CACNA1F
    CACNA1A["CACNA1A"]
    CACNA2D1 -->|"associated with"| CACNA1A
    AND["AND"]
    CACNA2D1 -->|"associated with"| AND
    CCS["CCS"]
    CACNA2D1 -->|"contributes to"| CCS
    CACNA2D2["CACNA2D2"]
    CACNA2D1 -->|"associated with"| CACNA2D2
    CACNA1C["CACNA1C"]
    CACNA2D1 -->|"associated with"| CACNA1C
    CACNA1I["CACNA1I"]
    CACNA2D1 -->|"associated with"| CACNA1I
    CACNA1A["CACNA1A"]
    CACNA1A -->|"associated with"| CACNA2D1
    CCS["CCS"]
    CCS -->|"contributes to"| CACNA2D1
    CACNA1C["CACNA1C"]
    CACNA1C -->|"associated with"| CACNA2D1
    CACNA2D2["CACNA2D2"]
    CACNA2D2 -->|"associated with"| CACNA2D1
    CACNA1F["CACNA1F"]
    CACNA1F -->|"associated with"| CACNA2D1
    CACNA1I["CACNA1I"]
    CACNA1I -->|"associated with"| CACNA2D1
    GENES["GENES"]
    GENES -->|"associated with"| CACNA2D1
    CACNA1G["CACNA1G"]
    CACNA1G -->|"associated with"| CACNA2D1
    CACNA1E["CACNA1E"]
    CACNA1E -->|"associated with"| CACNA2D1
    neurodegeneration["neurodegeneration"]
    CACNA2D1 -->|"implicated in"| neurodegeneration

Outgoing (18)

Target	Relation	Type	Str
AND	associated_with	gene	0.60
GAIN	contributes_to	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
CACNA2D2	interacts_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1E	interacts_with	protein	0.50
CACNA1H	interacts_with	protein	0.50
CACNA1G	interacts_with	protein	0.50
CACNA1A	interacts_with	gene	0.50
CACNA1C	interacts_with	gene	0.50

Incoming (21)

Source	Relation	Type	Str
CACNA1G	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1A	interacts_with	gene	0.60
CACNA1C	interacts_with	gene	0.60
CACNA1E	interacts_with	gene	0.60
CACNA1F	interacts_with	gene	0.60
CACNA1H	interacts_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1I	associated_with	gene	0.60
cacna1f	interacts_with	gene	0.50
CACNA1D	interacts_with	gene	0.50
CACNA2D2	interacts_with	gene	0.50
CACNA1I	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CACNA2D1 in their description or question text

No additional research found