gene 756 words KG: CACNA1C
Contents

CACNA1C Gene

🧬 Gene Info
Gene SymbolCACNA1C
AliasesPage for Cav1.2
FunctionCACNA1C encodes the alpha-1C subunit of the L-type voltage-gated calcium channel (Cav1.2), one of the most important calcium channels in neurons and cardiac myocytes
Primary Expressionthe brain, heart, and smooth muscle
Subcellular LocalizationSomatodendritic compartment, dendritic spines, cardiac cells
Molecular Weight250 kDa
PathwaysWnt signaling, oxidative stress response
UniProt IDQ13936
GeneCardsCACNA1C
Human Protein AtlasCACNA1C
Associated DiseasesAlzheimer, Anxiety, Cancer, Inflammation, Ms, psychiatric disorders
InteractionsAPP, CACNA1A, CACNA1D, CACNA1E, cacna1f, CACNA1F
KG Connections220 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

blarcamesine-axon
clinical_trial · KG edge: associated_with
CACNA1A — Calcium Channel Alpha-1A Subunit
gene · KG edge: associated_with
CACNA1B Gene
gene · KG edge: causes
CACNA1D Gene
gene · KG edge: associated_with
CACNA1E Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PIEZO1 expressed_in CACNA1C
KCNK2 associated_with CACNA1C
SCN5A associated_with CACNA1C
TRPM7 associated_with CACNA1C
SCN1A associated_with CACNA1C
TRPV4 expressed_in CACNA1C
CACNA1B associated_with CACNA1C
SCNN1A associated_with CACNA1C
CFTR associated_with CACNA1C
PIEZO2 associated_with CACNA1C

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