protein 1,089 words KG: CACNA1C
Contents

Cav1.2 - Voltage-Gated L-Type Calcium Channel (CACNA1C)

🔬 Protein Info
Gene SymbolCACNA1C
AliasesPage for Cav1.2
FunctionCACNA1C encodes the alpha-1C subunit of the L-type voltage-gated calcium channel (Cav1.2), one of the most important calcium channels in neurons and cardiac myocytes
Primary Expressionthe brain, heart, and smooth muscle
Subcellular LocalizationSomatodendritic compartment, dendritic spines, cardiac cells
Molecular Weight250 kDa
PathwaysWnt signaling, oxidative stress response
UniProt IDQ13936
GeneCardsCACNA1C
Human Protein AtlasCACNA1C
Associated DiseasesAlzheimer, Anxiety, Cancer, Inflammation, Ms, psychiatric disorders
InteractionsAPP, CACNA1A, CACNA1D, CACNA1E, cacna1f, CACNA1F
KG Connections217 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (8)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56

Related Analyses (9)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (5)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40
Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.40
Vascular Contribution to Alzheimer's Disease — Beyond Amyloi
validation · proposed · Score: 0.40

See Also (6)

blarcamesine-axon
clinical_trial · KG edge: associated_with
CACNA1A — Calcium Channel Alpha-1A Subunit
gene · KG edge: associated_with
CACNA1B Gene
gene · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with

Knowledge Graph (12 edges)

PIEZO1 expressed_in CACNA1C
KCNK2 associated_with CACNA1C
SCN5A associated_with CACNA1C
TRPM7 associated_with CACNA1C
SCN1A associated_with CACNA1C
TRPV4 expressed_in CACNA1C
CACNA1B associated_with CACNA1C
SCNN1A associated_with CACNA1C
CFTR associated_with CACNA1C
PIEZO2 associated_with CACNA1C

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