gene

cacna1f

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about cacna1f: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

25Outgoing

16Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	CACNA1F
Full Name	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha1F
Aliases	Page for CACNA1F Protein
Chromosome	Xp11.23
Function	is located on chromosome Xp11.23 and encodes the alpha1F subunit of voltage-gated calcium channels, known as Cav1.4
Primary Expression	retinal photoreceptors (both rods and cones) where it mediates the influx of calcium ions necessary for synaptic vesicle release and proper transmissi
Amino Acids	166 aa
UniProt ID	[O43497](https://www.uniprot.org/uniprot/O43497)
Ensembl ID	ENSG00000102040
GeneCards	CACNA1F
Human Protein Atlas	CACNA1F
Low-voltage activation threshold	Cav1.4 activates at more negative membrane potentials compared to other HVA channels
Slow deactivation kinetics	The channel remains open longer, supporting sustained calcium influx
Interaction with accessory subunits	Specifically associates with beta2 and alpha2delta-4 subunits in retinal cells
Rod photoreceptors	Critical for scotopic (low-light) vision
Associated Diseases	neurodegeneration research
Interactions	CACNA1A, CACNA1C, CACNA1D, CACNA1E, CACNA1G, CACNA1H
KG Connections	32 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CACNA1F — Calcium Voltage-Gated Channel Auxiliary Subunit Alpha1F

gene · 1656 words

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Pathway Diagram

graph TD
    CACNA1F["CACNA1F"]
    CACNA1F -->|"contributes to"| CCS["CCS"]
    CACNA1F -->|"interacts"| CACNA1D["CACNA1D"]
    CACNA1F -->|"interacts"| CACNA2D2["CACNA2D2"]
    CACNA1F -->|"interacts"| CACNA1I["CACNA1I"]
    CACNA1F -->|"interacts"| CACNA2D1["CACNA2D1"]
    CACNA1F -->|"interacts"| CACNA1E["CACNA1E"]
    CACNA1F -->|"interacts"| CACNA1H["CACNA1H"]
    CACNA1F -->|"interacts"| CACNA1G["CACNA1G"]
    CCS -->|"contributes to"| CACNA1F
    GAIN["GAIN"] -->|"contributes to"| CACNA1F

Outgoing (25)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CACNA1F	data_in	dataset_row	0.00
CACNA1I	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1G	interacts_with	gene	0.60
CACNA1H	interacts_with	gene	0.60
CACNA1I	interacts_with	gene	0.60
CACNA2D1	interacts_with	gene	0.60
CACNA2D2	interacts_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA1D	interacts_with	gene	0.50
CACNA2D2	interacts_with	gene	0.50
CACNA1I	interacts_with	gene	0.50
CACNA2D1	interacts_with	gene	0.50
CACNA1E	interacts_with	protein	0.50
CACNA1H	interacts_with	protein	0.50
CACNA1G	interacts_with	protein	0.50
CACNA1A	interacts_with	gene	0.50
CACNA1C	interacts_with	gene	0.50

Incoming (16)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CACNA1F	data_in	dataset_row	0.00
CACNA1I	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
GENES	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
GAIN	contributes_to	gene	0.60
CACNA1A	interacts_with	gene	0.60
CACNA1C	interacts_with	gene	0.60
CACNA1D	interacts_with	gene	0.60
CACNA1E	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning cacna1f in their description or question text

No additional research found