gene

CACNA1I

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNA1I: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

17Outgoing

22Incoming

0Experiments

0Debates

Summary

Page for CACNA1I Gene - Calcium Voltage-Gated Channel Subunit Alpha1 I

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🧬 Gene Info

Gene Symbol	CACNA1I
Full Name	CACNA1I - Calcium Voltage-Gated Channel Subunit Alpha1 I
Aliases	Page for CACNA1I Gene, Page for CACNA1I Protein
Chromosome	22q12.3
Protein Type	Gene
Function	Cav3.3 (T-type) calcium channels are crucial for
Amino Acids	226 aa
GeneCards	CACNA1I
Human Protein Atlas	CACNA1I
Neuronal rhythmicity	Generate low-threshold calcium spikes in thalamic and cortical neurons
Thalamic oscillations	Critical for sleep spindles and absence seizures
Dendritic integration	Mediate back-propagation of calcium signals
Gene expression	Activate calcium-dependent signaling cascades
Associated Diseases	neurodegeneration
Interactions	CACNA1A, CACNA1C, CACNA1D, CACNA1E, cacna1f, CACNA1F
KG Connections	39 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CACNA1I Gene - Calcium Voltage-Gated Channel Subunit Alpha1 I

gene · 726 words

→

CACNA1I Protein - Cav3.3 T-Type Calcium Channel

protein · 673 words

→

Pathway Diagram

graph TD
    CACNA1I["CACNA1I"]
    CACNA2D1["CACNA2D1"]
    CACNA1I -->|"associated with"| CACNA2D1
    CACNA1E["CACNA1E"]
    CACNA1I -->|"associated with"| CACNA1E
    CACNA1H["CACNA1H"]
    CACNA1I -->|"associated with"| CACNA1H
    CACNA1D["CACNA1D"]
    CACNA1I -->|"associated with"| CACNA1D
    CACNA1G["CACNA1G"]
    CACNA1I -->|"associated with"| CACNA1G
    CACNA1A["CACNA1A"]
    CACNA1A -->|"associated with"| CACNA1I
    CCS["CCS"]
    CCS -->|"contributes to"| CACNA1I
    CACNA1C["CACNA1C"]
    CACNA1C -->|"associated with"| CACNA1I
    CACNA2D2["CACNA2D2"]
    CACNA2D2 -->|"associated with"| CACNA1I
    CACNA1F["CACNA1F"]
    CACNA1F -->|"associated with"| CACNA1I
    GENES["GENES"]
    GENES -->|"associated with"| CACNA1I
    CACNA1G["CACNA1G"]
    CACNA1G -->|"associated with"| CACNA1I
    CACNA1E["CACNA1E"]
    CACNA1E -->|"associated with"| CACNA1I
    CACNA2D1["CACNA2D1"]
    CACNA2D1 -->|"associated with"| CACNA1I
    GAIN["GAIN"]
    GAIN -->|"contributes to"| CACNA1I
    AND["AND"]
    AND -->|"associated with"| CACNA1I
    CACNA1H["CACNA1H"]
    CACNA1H -->|"associated with"| CACNA1I
    CACNA1D["CACNA1D"]
    CACNA1D -->|"associated with"| CACNA1I
    CACNA2D1["CACNA2D1"]
    CACNA1I -->|"interacts with"| CACNA2D1
    CACNA1E["CACNA1E"]
    CACNA1I -->|"interacts with"| CACNA1E
    CACNA1H["CACNA1H"]
    CACNA1I -->|"interacts with"| CACNA1H
    CACNA1G["CACNA1G"]
    CACNA1I -->|"interacts with"| CACNA1G
    CACNA1A["CACNA1A"]
    CACNA1I -->|"interacts with"| CACNA1A
    CACNA1C["CACNA1C"]
    CACNA1I -->|"interacts with"| CACNA1C
    Genes["Genes"]
    CACNA1I -->|"interacts with"| Genes
    cacna1f["cacna1f"]
    cacna1f -->|"interacts with"| CACNA1I
    CACNA1D["CACNA1D"]
    CACNA1D -->|"interacts with"| CACNA1I
    CACNA2D2["CACNA2D2"]
    CACNA2D2 -->|"interacts with"| CACNA1I
    neurodegeneration["neurodegeneration"]
    CACNA1I -->|"implicated in"| neurodegeneration

Outgoing (17)

Target	Relation	Type	Str
CACNA2D1	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1G	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA2D2	interacts_with	gene	0.60
CACNA2D1	interacts_with	gene	0.50
CACNA1E	interacts_with	protein	0.50
CACNA1H	interacts_with	protein	0.50
CACNA1G	interacts_with	protein	0.50
CACNA1A	interacts_with	gene	0.50
CACNA1C	interacts_with	gene	0.50

Incoming (22)

Source	Relation	Type	Str
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
CCS	contributes_to	gene	0.60
CACNA1C	associated_with	gene	0.60
CACNA2D2	associated_with	gene	0.60
CACNA1F	associated_with	gene	0.60
CACNA1G	interacts_with	gene	0.60
CACNA1H	interacts_with	gene	0.60
CACNA1A	interacts_with	gene	0.60
CACNA1C	interacts_with	gene	0.60
CACNA1E	interacts_with	gene	0.60
CACNA1F	interacts_with	gene	0.60
CACNA1G	associated_with	gene	0.60
CACNA1E	associated_with	gene	0.60
CACNA2D1	associated_with	gene	0.60
GAIN	contributes_to	gene	0.60
CACNA1H	associated_with	gene	0.60
CACNA1D	associated_with	gene	0.60
CACNA1D	interacts_with	gene	0.50
CACNA2D2	interacts_with	gene	0.50
cacna1f	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CACNA1I in their description or question text

No additional research found