Contents

BCL2 Gene

🧬 Gene Info

Gene Symbol	BCL2
Aliases	B-cell lymphoma 2
Protein Family	BCL-2 family (anti-apoptotic subfamily)
Function	Direct BAX/BAK inhibition
Molecular Weight	26 kDa
Pathways	Akt, Apoptosis, Autophagy, BMP signaling, Bh4 Domain
UniProt ID	P10415
GeneCards	BCL2
Human Protein Atlas	BCL2
BH3 domain	Required for interaction with pro-apoptotic family members
Transmembrane domain	Anchors BCL2 to the outer mitochondrial membrane, ER, and nuclear envelope
BH1 domain	Forms part of the hydrophobic pocket that binds BH3 domains
BH2 domain	Contributes to the binding interface for pro-apoptotic proteins
N-terminal flexible region	Contains regulatory sequences
Phosphorylation	BCL2 is phosphorylated on multiple serine/threonine residues
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	Abt263, ABT263, ABT-737, Adcs, berberine, BERBERINE
Interactions	ABCD3, ABP, ACETYL-COA, ACHE, Actin, AD
KG Connections	2857 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING