| Gene Symbol | BCL2L1 |
| Chromosome | 20q11.21 |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | is a gene located on chromosome 20q11.21 that encodes a member of the BCL-2 family of proteins |
| Mechanism of Action | Small molecule inhibitor of anti-apoptotic protein function |
| Primary Expression | Cerebral cortex, Hippocampus, Substantia nigra, Spinal cord |
| Subcellular Localization | </th><td>Mitochondrial outer membrane; endoplasmic reticulum; nucleus</td></tr> |
| Druggability | High (0.80) |
| Clinical Stage | Approved |
| Pathways | Akt, Nf-Κb, Pi3K, Toll-Like Receptor |
| UniProt ID | Q07817 |
| NCBI Gene ID | 598 |
| Ensembl ID | ENSG00000171552 |
| OMIM | 300040 |
| GeneCards | BCL2L1 |
| Human Protein Atlas | BCL2L1 |
| Associated Diseases | Als, Cancer, Carcinoma, Cardiovascular |
| Known Drugs/Compounds | Abt263, ABT263, rapamycin |
| Interactions | AGING, AKT, AMPK, AMYLOID, AND, APOPTOSIS |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Senescent Microglia Resolution via Maresins-Senoly |
| KG Connections | 558 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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