| Gene Symbol | BCL2A1 |
| Aliases | BCL2A1PROTEIN |
| Chromosome | 15q24.2 |
| Protein Family | BCL2 family (anti-apoptotic) |
| Function | BCL2A1 encodes an anti-apoptotic protein that regulates the intrinsic (mitochondrial) apoptosis pathway: |
| Primary Expression | hematopoietic cells but is also induced in neurons under stress conditions[@bcla2010] |
| Subcellular Localization | ** Cytoplasm, mitochondria, nucleus |
| Amino Acids | 175 aa |
| UniProt ID | Q9GZW8 |
| NCBI Gene ID | 602 |
| GeneCards | BCL2A1 |
| Human Protein Atlas | BCL2A1 |
| BH3 domain | Present but non-canonical; mediates some protein interactions |
| BH1 domain | Critical for forming heterodimers with pro-apoptotic proteins |
| BH2 domain | Contributes to protein-protein interactions |
| Associated Diseases | neurodegeneration |
| Interactions | APOPTOSIS, BCL2, CANCER, CASP3, CASP6, CEBPB |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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