Contents

BCL2L1 Gene

🧬 Gene Info

Gene Symbol	BCL2L1
Chromosome	20q11.21
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	is a gene located on chromosome 20q11.21 that encodes a member of the BCL-2 family of proteins
Mechanism of Action	Small molecule inhibitor of anti-apoptotic protein function
Primary Expression	Cerebral cortex, Hippocampus, Substantia nigra, Spinal cord
Druggability	High (0.80)
Clinical Stage	Approved
Pathways	Akt, Nf-Κb, Pi3K, Toll-Like Receptor
UniProt ID	Q07817
NCBI Gene ID	598
Ensembl ID	ENSG00000171552
OMIM	300040
GeneCards	BCL2L1
Human Protein Atlas	BCL2L1
Associated Diseases	Als, Cancer, Carcinoma, Cardiovascular
Known Drugs/Compounds	Abt263, ABT263, rapamycin
Interactions	AGING, AKT, AMPK, AMYLOID, AND, APOPTOSIS
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Senescent Microglia Resolution via Maresins-Senoly
KG Connections	563 knowledge graph edges
Databases	GeneCards HPA STRING

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Knowledge Graph

ALOX15 co_discussed BCL2L1

BCL2L1 co_discussed TFRC

BCL2L1 co_discussed GPR37

BCL2L1 co_discussed CMKLR1

BCL2L1 co_discussed ALOX12

BCL2L1 co_discussed ALOX5

IL1B activates BCL2L1

BCL2L1 expressed_in EGFR

ULK1 associated_with BCL2L1