Contents

BCL2 Protein

🔬 Protein Info

Gene Symbol	BCL2
Aliases	B-cell lymphoma 2
Protein Family	BCL-2 family (anti-apoptotic subfamily)
Function	Direct BAX/BAK inhibition
Subcellular Localization	</strong></td><td>Mitochondrial outer membrane, ER membrane, Nuclear envelope</td></tr>
Molecular Weight	26 kDa
Pathways	Akt, Apoptosis, Autophagy, BMP signaling, Bh4 Domain
UniProt ID	P10415
GeneCards	BCL2
Human Protein Atlas	BCL2
BH1 Domain	Forms the hydrophobic pocket for binding pro-apoptotic proteins
BH2 Domain	Contributes to BH3 domain binding
BH3 Domain	Critical for interaction with pro-apoptotic family members
BH4 Domain	N-terminal domain important for anti-apoptotic function
Transmembrane Domain	C-terminal anchor for mitochondrial membrane localization
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	Abt263, ABT263, ABT-737, Adcs, berberine, BERBERINE
Interactions	ABCD3, ABP, ACETYL-COA, ACHE, Actin, AD
KG Connections	2857 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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