gene 1,024 words KG: BCL2L12
Contents

BCL2L12 Gene

🧬 Gene Info
Gene SymbolBCL2L12
Chromosome19q13.33
Functionis a member of the BCL-2 protein family with predominantly anti-apoptotic functions.
Primary Expressionglioblastoma, emerging research suggests important roles in neuronal survival and neurodegeneration
Molecular Weight34 kDa
Amino Acids297 aa
Exons5
PathwaysNF-κB signaling
UniProt IDQ9Y235
NCBI Gene ID83696
GeneCardsBCL2L12
Human Protein AtlasBCL2L12
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsINFLAMMATION, NF-ΚB, P38, STAT6
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Senescence-Activated NAD+ Depletion Rescue
Score: 0.76
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (7)

Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
BCL2 Gene
gene · KG edge: expressed_in
STAT6 — Signal Transducer and Activator of Transcriptio
gene · KG edge: activates
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in

Knowledge Graph (12 edges)

BCL2 expressed_in BCL2L12
BCL2L12 activates P38
BCL2L12 expressed_in BCL2
BCL2L12 activates STAT6
BCL2 FAMILY associated_with BCL2L12
APOPTOSIS expressed_in BCL2L12
BCL2L12 activates Ms
BCL2L12 activates Leukemia
BCL2L12 expressed_in Apoptosis
BCL2L12 activates NF-ΚB

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