gene

BECLIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BECLIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

625Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

BECLIN1 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with Aging, Als, Alzheimer. Connected to 407 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	BECLIN1
Full Name	BECN1
Chromosome	17q21
Protein Type	Gene
Function	is a gene/protein encoding a key neuronal protein involved in synaptic function, signal transduction, and cellular homeostasis
Pathways	Apoptosis, Autophagy, Mtor, Oxidative Stress
GeneCards	BECLIN1
Human Protein Atlas	BECLIN1
Associated Diseases	Als, Alzheimer, Cancer, Colorectal Cancer, Glioblastoma, Inflammation
Interactions	ABCA1, ACTB, ADSL, AKT, AKT1, ALZHEIMER
KG Connections	622 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Beclin-1

protein · 1419 words

→

Pathway Diagram

flowchart TD
    BECLIN1["BECLIN1
Autophagy Regulator"]
    
    BCL2["BCL2
Anti-apoptotic Protein"]
    PI3K["PI3K
Kinase Pathway"]
    MTOR["mTOR
Growth Regulator"]
    AKT["AKT
Survival Kinase"]
    
    AUTOPHAGY["Autophagy
Cellular Cleanup"]
    APOPTOSIS["Apoptosis
Cell Death"]
    OXIDATIVE["Oxidative Stress
Response"]
    BBB["Blood-Brain Barrier
Integrity"]
    
    P62["P62/SQSTM1
Autophagy Receptor"]
    HO1["HO-1
Antioxidant Enzyme"]
    SIGMAR1["SIGMAR1
ER Stress Sensor"]
    
    ALS["ALS
Motor Neuron Disease"]
    MS["Multiple Sclerosis
Demyelination"]
    INFLAMMATION["Neuroinflammation"]
    ANXIETY["Anxiety Disorders"]
    
    BECLIN1 -->|"forms complex"| PI3K
    PI3K -->|"activates"| AUTOPHAGY
    BECLIN1 -->|"inhibited by"| BCL2
    BECLIN1 -->|"regulated by"| MTOR
    MTOR -->|"inhibits"| AUTOPHAGY
    AKT -->|"activates"| MTOR
    
    AUTOPHAGY -->|"clears"| P62
    AUTOPHAGY -->|"protects"| BBB
    BECLIN1 -->|"upregulates"| HO1
    HO1 -->|"reduces"| OXIDATIVE
    
    BECLIN1 -->|"interacts"| SIGMAR1
    SIGMAR1 -->|"modulates"| OXIDATIVE
    
    BECLIN1 -->|"dysregulated in"| ALS
    BECLIN1 -->|"contributes to"| MS
    BECLIN1 -->|"reduces"| INFLAMMATION
    BECLIN1 -->|"associated with"| ANXIETY
    
    BCL2 -->|"promotes"| APOPTOSIS
    
    style BECLIN1 fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style HO1 fill:#1b5e20
    style BBB fill:#1b5e20
    style BCL2 fill:#4a1a6b
    style PI3K fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style AKT fill:#4a1a6b
    style SIGMAR1 fill:#4a1a6b
    style OXIDATIVE fill:#ef5350
    style APOPTOSIS fill:#ef5350
    style INFLAMMATION fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style ANXIETY fill:#5d4400

Outgoing (417)

Target	Relation	Type	Str
Als	activates	disease	1.00
AUTOPHAGY	activates	gene	1.00
P62	activates	gene	1.00
Autophagy	activates	pathway	1.00
LC3	activates	gene	1.00
Autophagy	associated_with	pathway	1.00
Macroautophagy	involved_in	process	0.95
LC3	associated_with	gene	0.90
AMPK	activates	gene	0.90
Autophagy	inhibits	pathway	0.90
AUTOPHAGY	regulates	gene	0.90
Apoptosis	activates	pathway	0.90
Mtor	associated_with	pathway	0.90
Autophagy	regulates	pathway	0.90
Tumor	inhibits	disease	0.85
Inflammation	activates	disease	0.85
P62	associated_with	gene	0.80
MTOR	associated_with	gene	0.80
Hepatocellular Carcinoma	activates	disease	0.75
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
Cancer	inhibits	disease	0.75
Cancer	associated_with	disease	0.75
Als	interacts_with	disease	0.75
Carcinoma	activates	disease	0.75
Inflammation	regulates	disease	0.75
Neuroinflammation	activates	disease	0.75
Infection	activates	disease	0.75
Als	regulates	disease	0.75
AUTOPHAGY	inhibits	gene	0.70
BCL-2	activates	gene	0.70
PARKIN	activates	gene	0.70
Pi3K/Akt	activates	pathway	0.70
Apoptosis	regulates	pathway	0.70
CANCER	activates	gene	0.70
CANCER	associated_with	gene	0.70
MITOCHONDRIA	activates	gene	0.70
NEURON	activates	gene	0.70
Mitophagy	activates	pathway	0.70
Er Stress	activates	pathway	0.70
Oxidative Stress	inhibits	pathway	0.70
ATG7	activates	gene	0.70
MICROGLIA	activates	gene	0.70
CANCER	inhibits	gene	0.70
ULK1	activates	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
TNF-Α	activates	gene	0.70
NEUROINFLAMMATION	activates	gene	0.70
AKT	associated_with	gene	0.70
Mtor	expressed_in	pathway	0.70

Incoming (208)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	1.00
AMBRA1	interacts_with	protein	0.95
BCL2	associated_with	protein	0.90
BCL2	disrupts	gene	0.90
ATG5	activates	gene	0.90
AUTOPHAGY	associated_with	gene	0.90
Voacamine	activates	chemical	0.80
acupuncture	regulates	drug	0.80
APOPTOSIS	activates	gene	0.80
ROS	activates	gene	0.80
ROS	associated_with	gene	0.70
MITOPHAGY	activates	gene	0.70
TNF	activates	gene	0.70
PI3K	associated_with	gene	0.70
AUTOPHAGY	inhibits	gene	0.70
PINK1	activates	gene	0.70
AND	protects_against	gene	0.60
GOT1	activates	gene	0.60
SQSTM1	activates	gene	0.60
GPT	activates	gene	0.60
ELAVL1	activates	gene	0.60
GPX4	activates	gene	0.60
FGF18	expressed_in	gene	0.60
BECN1	activates	gene	0.60
TGFB1	activates	gene	0.60
ACTB	activates	gene	0.60
P62	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
AND	associated_with	gene	0.60
FTH1	activates	gene	0.60
NCOA4	activates	gene	0.60
OPA1	expressed_in	gene	0.60
CASP3	activates	gene	0.60
AKT1	activates	gene	0.60
MYC	activates	gene	0.60
IL1B	activates	gene	0.60
TP53	activates	gene	0.60
SRC	activates	gene	0.60
IL6	activates	gene	0.60
EGFR	activates	gene	0.60
HSP90AA1	activates	gene	0.60
ERN1	associated_with	gene	0.60
MAP1LC3B	activates	gene	0.60
AMYLOID	inhibits	gene	0.60
MAPK	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
APP/PS1	associated_with	gene	0.60
MAVS	activates	gene	0.60
APAF1	regulates	gene	0.60
CASPASE3	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BECLIN1 in their description or question text

No additional research found