gene

EPHB3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

4Outgoing

3Incoming

0Experiments

0Debates

Summary

EPHB3 encodes a receptor tyrosine kinase critical for neural development, synaptic plasticity, and cell positioning. EPHB3 signaling is implicated in Alzheimer's disease, Parkinson's disease, and cancer, with roles in dendritic spine formation and neural circuit development.

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🧬 Gene Info

Gene Symbol	EPHB3
Full Name	Eph Receptor B3
Chromosome	3q27.1
Protein Type	Receptor
Function	encodes a member of the Eph family of receptor tyrosine kinases.
Primary Expression	various brain regions:
Amino Acids	998 aa
Exons	19
UniProt ID	P54753
NCBI Gene ID	2049
Ensembl ID	ENSG00000149932
OMIM	601067
GeneCards	EPHB3
Human Protein Atlas	EPHB3
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	ASTROCYTE, AXON, INFLAMMATION, MICROGLIA
KG Connections	7 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EPHB3 — AlphaFold P54753 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EPHB3 Gene

gene · 1385 words

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Pathway Diagram

flowchart TD
    N0["EPHB3"]
    N1["Autoimmune"]
    N0 -->|"interacts with"| N1
    N2["Multiple Sclerosis"]
    N0 -->|"interacts with"| N2
    N3["Inflammation"]
    N0 -->|"interacts with"| N3
    N4["AXON"]
    N0 -->|"interacts with"| N4
    N5["INFLAMMATION"]
    N5 -->|"interacts with"| N0
    N6["ASTROCYTE"]
    N6 -->|"inhibits"| N0
    N7["AND"]
    N7 -->|"inhibits"| N0
    N8["MICROGLIA"]
    N8 -->|"inhibits"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene

Outgoing (4)

Target	Relation	Type	Str
Autoimmune	interacts_with	disease	0.65
Multiple Sclerosis	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
AXON	interacts_with	gene	0.60

Incoming (3)

Source	Relation	Type	Str
INFLAMMATION	interacts_with	gene	0.60
ASTROCYTE	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EPHB3 in their description or question text

No additional research found