concept

ATAXIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATAXIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

794Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ATAXIA is a concept in neurodegeneration research. Key relationships include: activates, co discussed, transports. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 50 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ATAXIA
Key Genes/Proteins	ACHE, AMPK, ATG7, BCL2, BECN1, CGAS
Related Diseases	ALS, ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Deep-Cerebellar-Nuclei-in-Ataxia

cell_type · 3235 words

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Pathway Diagram

graph TD
    ATAXIA["ATAXIA"]
    ATAXIA -->|"target for"| Immune_Response["Immune Response"]
    ATAXIA -->|"activates"| Oxidative_Stress["Oxidative Stress"]
    ATAXIA -->|"target for"| Mitochondrial_Function["Mitochondrial Function"]
    CALCINEURIN["CALCINEURIN"] -->|"activates"| ATAXIA
    ATG12["ATG12"] -->|"activates"| ATAXIA
    ATG10["ATG10"] -->|"activates"| ATAXIA
    HSPA1A["HSPA1A"] -->|"regulates"| ATAXIA
    DNAJB1["DNAJB1"] -->|"regulates"| ATAXIA
    GENES["GENES"] -->|"activates"| ATAXIA
    DNA["DNA"] -->|"target for"| ATAXIA

Outgoing (241)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
Als	associated_with	disease	0.95
Neurodegeneration	associated_with	disease	0.85
Parkinson	associated_with	disease	0.85
Dementia	associated_with	disease	0.75
Parkinson	activates	disease	0.75
Oxidative Stress	activates	pathway	0.70
Mitochondrial Function	inhibits	pathway	0.70
PURKINJE	sensitizes_to	cell_type	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	causes	disease	0.65
LEVODOPA	mediates	drug	0.65
ROS	phosphorylates	gene	0.65
FRONTOTEMPORAL DEMENTIA	exacerbates	disease	0.65
FRONTOTEMPORAL DEMENTIA	transports	disease	0.65
RAPAMYCIN	interacts_with	drug	0.65
ROS	regulates	gene	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
CEREBELLUM	reduces	brain_region	0.65
Als	therapeutic_target	disease	0.65
Stroke	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	activates	disease	0.65
SQSTM1	activates	gene	0.65
Aging	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
NEURON	mediates	cell_type	0.60
PARKIN	mediates	gene	0.60
PARKINSON	mediates	disease	0.60
PARKINSON'S	mediates	disease	0.60
PARKINSON'S DISEASE	mediates	disease	0.60
MOTOR NEURON	mediates	cell_type	0.60
Immune Response	therapeutic_target	pathway	0.60
Apoptosis	activates	pathway	0.60
P62	interacts_with	gene	0.60
ULK1	activates	gene	0.60
TFEB	interacts_with	gene	0.60
HTT	transports	gene	0.60
BECN1	activates	gene	0.60
MOTOR NEURON	causes	cell_type	0.60
FRONTOTEMPORAL	transports	disease	0.60
MTOR	causes	gene	0.60
SOD1	promotes	gene	0.60
TARDBP	activates	gene	0.60
DEMENTIA	transports	disease	0.60
FTD	transports	disease	0.60
LC3	causes	gene	0.60
HUNTINGTON	activates	disease	0.60

Incoming (553)

Source	Relation	Type	Str
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
GENES	activates	gene	0.95
NEURODEGENERATION	associated_with	gene	0.95
HUNTINGTON	associated_with	gene	0.95
DEMENTIA	associated_with	gene	0.95
PARKINSON	associated_with	gene	0.95
ALS	associated_with	gene	0.85
PARKINSON	activates	gene	0.85
DNA	activates	gene	0.85
DNA	associated_with	gene	0.85
ATM	activates	gene	0.85
Huntington	associated_with	disease	0.85
Stress Granule Formation	protects_against	process	0.85
Reducing Stress Granule Formation	contributes_to	process	0.85
CANCER	activates	gene	0.85
ENDOSOMES	associated_with	gene	0.75
GAIN	associated_with	gene	0.75
NRF2	therapeutic_target	gene	0.75
P53	activates	gene	0.75
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.75
HUNTINGTON'S DISEASE	associated_with	gene	0.75
DRP1	associated_with	gene	0.75
POLG	associated_with	gene	0.75
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.75
MITOPHAGY	inhibits	gene	0.75
PARKINSON'S DISEASE	associated_with	gene	0.75
C9ORF72	associated_with	gene	0.75
HUNTINGTON	activates	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
DNA	therapeutic_target	gene	0.75
ALZHEIMER	associated_with	gene	0.75
ALZHEIMER	activates	gene	0.75
SCA3	associated_with	gene	0.75
NEUROINFLAMMATION	therapeutic_target	gene	0.75
NEURODEGENERATION	regulates	gene	0.75
NEURODEGENERATIVE DISEASES	associated_with	gene	0.75
ATXN1	causes	gene	0.75
BDNF	protects_against	gene	0.75
AMYLOID	implicated_in	gene	0.75
APP	implicated_in	gene	0.75
MITOCHONDRIAL DNA	associated_with	gene	0.65
AGING	associated_with	gene	0.65
SCA7	associated_with	gene	0.65
NEURODEGENERATIVE DISEASES	causes	gene	0.65
ACTB	associated_with	gene	0.65
UCHL1	associated_with	gene	0.65
BRAIN INJURY	implicated_in	gene	0.65
NEURODEGENERATION	expressed_in	gene	0.65
CAG REPEATS	causes	gene	0.65
NEURON	expressed_in	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATAXIA in their description or question text

No additional research found