Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AD pathology: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Aβ42:Aβ40 Ratio | biomarker_for | biomarker | 0.93 |
| Amyloid Probability Score 2 | biomarker_for | biomarker | 0.93 |
| MAPT | associated_with | protein | 0.92 |
| GFAP | indicates | protein | 0.90 |
| 29552443 | is less evident in NHD than | paper | 0.90 |
| 29552443 | is less evident in | paper | 0.90 |
| 41542441 | does not result in | paper | 0.90 |
| 39272998 | has been proven to be a major contributor to | paper | 0.90 |
| 39272998 | is a major contributor to | paper | 0.90 |
| TREM2 | regulates | protein | 0.85 |
| Excitatory Neurons | associated_with | cell_type | 0.82 |
| Cognitive Resilience | associated_with | phenotype | 0.80 |
| GFAP | regulates | gene | 0.75 |
| synaptic dysfunction | causes | mechanism | 0.70 |
| 41942760 | associated with | paper | 0.60 |
| 41542441 | no reduction in | paper | 0.60 |
| 31392412 | spreads via | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.720
neurodegeneration | 2026-04-16 | 1 hypotheses
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.500
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.541
neurodegeneration | 2026-04-13 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.68 · 2026-04-25
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.68 · 2026-04-16
closed · Rounds: 4 · Score: 0.92 · 2026-04-03
closed · Rounds: 4 · Score: 0.56 · 2026-04-02
Hypotheses and analyses mentioning AD pathology in their description or question text
No additional research found