gene

H3F3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about H3F3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

56Connections

0Hypotheses

0Analyses

36Outgoing

20Incoming

0Experiments

0Debates

Summary

H3F3A is a gene implicated in neurodegeneration research. Key relationships include: associated with, biomarker for, implicated in. Associated with AD, Als, Cancer. Connected to 41 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	H3F3A
Full Name	H3.3 Histone A
Aliases	Page for H3F3A
Chromosome	1q42.12
Function	is a crucial component of chromatin regulation in eukaryotic cells.
Amino Acids	136 aa
UniProt ID	[P84243](https://www.uniprot.org/uniprot/P84243)
Ensembl ID	ENSG00000163041
OMIM	601128
GeneCards	H3F3A
Human Protein Atlas	H3F3A
Associated Diseases	AD, cancer, glioma, gliomas, Ms, pilocytic astrocytoma
KG Connections	56 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

H3F3A — H3.3 Histone A

gene · 1554 words

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Pathway Diagram

graph TD
    H3F3A["H3F3A"]
    Cancer{"Cancer"}
    H3F3A -->|"biomarker for"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    H3F3A -->|"biomarker for"| Neurodegeneration
    Ms{"Ms"}
    H3F3A -->|"biomarker for"| Ms
    Glioma{"Glioma"}
    H3F3A -->|"biomarker for"| Glioma
    OVERVIEW["OVERVIEW"]
    H3F3A -->|"biomarker for"| OVERVIEW
    BRAF["BRAF"]
    H3F3A -->|"associated with"| BRAF
    ATRX["ATRX"]
    H3F3A -->|"associated with"| ATRX
    JUN["JUN"]
    H3F3A -->|"biomarker for"| JUN
    IDH1["IDH1"]
    H3F3A -->|"associated with"| IDH1
    CIC["CIC"]
    H3F3A -->|"associated with"| CIC
    TERT["TERT"]
    H3F3A -->|"associated with"| TERT
    NEURODEGENERATION["NEURODEGENERATION"]
    H3F3A -->|"biomarker for"| NEURODEGENERATION
    IDH1 -->|"associated with"| H3F3A
    TERT -->|"associated with"| H3F3A
    JUN -->|"biomarker for"| H3F3A
    CIC -->|"associated with"| H3F3A
    FUBP1["FUBP1"]
    FUBP1 -->|"associated with"| H3F3A
    BRAF -->|"associated with"| H3F3A
    ATRX -->|"associated with"| H3F3A
    OVERVIEW -->|"biomarker for"| H3F3A
    AND["AND"]
    AND -->|"associated with"| H3F3A
    CANCER["CANCER"]
    CANCER -->|"biomarker for"| H3F3A
    style H3F3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (36)

Target	Relation	Type	Str
BRAIN TUMOURS	associated_with	entity	0.85
gliomas	associated_with	disease	0.80
Als	therapeutic_target	disease	0.65
Glioma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Glioma	biomarker_for	disease	0.65
BRAF	biomarker_for	gene	0.60
CIC	biomarker_for	gene	0.60
ATRX	biomarker_for	gene	0.60
Mismatch Repair	expressed_in	pathway	0.60
JUN	biomarker_for	gene	0.60
IDH1	associated_with	gene	0.60
CIC	associated_with	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
CANCER	biomarker_for	gene	0.60
Raf	associated_with	protein	0.60
Fus	associated_with	protein	0.60
App	biomarker_for	protein	0.60
TERT	associated_with	gene	0.60
FUBP1	associated_with	gene	0.60
OVERVIEW	biomarker_for	gene	0.60
BRAF	associated_with	gene	0.60
ATRX	associated_with	gene	0.60
IDH1	biomarker_for	gene	0.60
TERT	biomarker_for	gene	0.60
cancer	implicated_in	disease	0.50
pilocytic astrocytoma	implicated_in	disease	0.50
glioma	implicated_in	disease	0.50
AD	implicated_in	disease	0.50
Ms	implicated_in	disease	0.50
RA	implicated_in	disease	0.50
SS	implicated_in	disease	0.50

Incoming (20)

Source	Relation	Type	Str
CANCER	therapeutic_target	gene	0.60
ATRX	associated_with	gene	0.60
NEURODEGENERATION	biomarker_for	gene	0.60
IDH1	associated_with	gene	0.60
TERT	associated_with	gene	0.60
JUN	biomarker_for	gene	0.60
CIC	associated_with	gene	0.60
FUBP1	associated_with	gene	0.60
OVERVIEW	biomarker_for	gene	0.60
PTEN	expressed_in	gene	0.60
BRAF	therapeutic_target	gene	0.60
RET	expressed_in	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
TERT	biomarker_for	gene	0.60
FUBP1	biomarker_for	gene	0.60
CANCER	biomarker_for	gene	0.60
ATRX	biomarker_for	gene	0.60
BRAF	biomarker_for	gene	0.60
CIC	biomarker_for	gene	0.60
BRAF	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning H3F3A in their description or question text

No additional research found