protein

CHIP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

156Connections

8Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for CHIP Protein (STUB1)

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🔬 Protein Info

Gene Symbol	CHIP
Aliases	STUB1
Function	E3 ubiquitin ligase catalytic domain
Molecular Weight	34.5 kDa
Pathways	Dna Repair, Dna Damage Response
GeneCards	CHIP
Human Protein Atlas	CHIP
Location	C-terminal region
Binding	Binds to the C-terminal EEVD motif of chaperones
Importance	Required for full ubiquitin ligase activity
Mechanism	Interacts with E2 ubiquitin-conjugating enzymes
Misfolded proteins	Endoplasmic reticulum proteins
Chaperone clients	HSP70/HSP90 substrates
Disease proteins	Aggregation-prone proteins
Heat shock	Regulates HSF1 activity
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, cardiovascular disease, Chronic Kidney Disease
Interactions	ACTB, ALS4, ALZHEIMER, AMYLOID, amyotrophic lateral sclerosis, APP
KG Connections	148 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHIP["CHIP"]
    Cardiovascular_Disease{"Cardiovascular Disease"}
    CHIP -->|"risk factor for"| Cardiovascular_Disease
    Leukemia{"Leukemia"}
    CHIP -->|"risk factor for"| Leukemia
    Inflammation(["Inflammation"])
    CHIP -->|"causes"| Inflammation
    COPD{"COPD"}
    CHIP -->|"associated with"| COPD
    Chronic_Kidney_Disease{"Chronic Kidney Disease"}
    CHIP -->|"associated with"| Chronic_Kidney_Disease
    Stroke{"Stroke"}
    CHIP -->|"associated with"| Stroke
    Pulmonary_Embolism{"Pulmonary Embolism"}
    CHIP -->|"associated with"| Pulmonary_Embolism
    Alzheimer_s_Disease{"Alzheimer's Disease"}
    CHIP -->|"protects against"| Alzheimer_s_Disease
    Epigenetic_Regulators["Epigenetic Regulators"]
    Epigenetic_Regulators -->|"involved in"| CHIP
    style CHIP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (92)

Target	Relation	Type	Str
Cardiovascular Disease	associated_with	disease	0.95
Acute Myeloid Leukemia	risk_factor_for	disease	0.90
CARDIOVASCULAR DISEASE	associated_with	entity	0.90
Leukemia	risk_factor_for	disease	0.90
Inflammation	causes	process	0.85
inflammation	promotes	process	0.85
Myocardial Infarction	risk_factor_for	disease	0.85
Coronary Artery Disease	risk_factor_for	disease	0.85
NEUROINFLAMMATION	modulates	entity	0.80
ALZHEIMER'S DISEASE	protects_against	entity	0.80
Malignancy	associated_with	disease	0.80
cardiovascular disease	implicated_in	disease	0.80
Pulmonary Embolism	associated_with	disease	0.75
Stroke	associated_with	disease	0.75
COPD	associated_with	disease	0.75
Chronic Kidney Disease	associated_with	disease	0.75
Alzheimer's Disease	protects_against	disease	0.70
Chronic Obstructive Pulmonary Disease	associated_with	disease	0.70
mitophagy	inhibits	process	0.70
SCA48	causes	disease	0.70
SCAR16	causes	disease	0.70
CKD	associated_with	disease	0.70
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
WAS	co_discussed	protein	0.50
HSP40	co_expressed_with	protein	0.50
DENDRITIC SPINE	regulates	concept	0.50
HDAC2	activates	gene	0.50
HSC70	co_expressed_with	protein	0.50
Macrophage	inhibits	cell_type	0.50
HUNTINGTIN	activates	protein	0.50
DNMT1	activates	protein	0.50
DEMENTIA	activates	gene	0.50
amyotrophic lateral sclerosis	activates	gene	0.50
MAP1LC3	activates	gene	0.50
FRONTOTEMPORAL DEMENTIA	activates	disease	0.50
MTORC1	activates	concept	0.50
Ataxia	activates	disease	0.50
Neuron	activates	cell_type	0.50
Spinocerebellar Ataxia	activates	disease	0.50
FRONTOTEMPORAL	activates	concept	0.50
DNA DAMAGE	activates	concept	0.50
MOTOR NEURON	activates	concept	0.50
Dna Damage Response	activates	pathway	0.50
HOMOLOGOUS RECOMBINATION	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
Stem Cell	activates	cell_type	0.50

Incoming (64)

Source	Relation	Type	Str
40323531	facilitates proteostasis of	paper	0.90
40323531	has	paper	0.90
40323531	maintains	paper	0.90
40323531	has dual	paper	0.90
40323531	facilitates proteostasis by promoting degradation of	paper	0.90
EPIGENETIC REGULATORS	involved_in	entity	0.85
DNA REPAIR GENES	involved_in	entity	0.85
Epigenetic Regulators	involved_in	protein	0.80
40323531	has potential as	paper	0.60
40323531	is targeted for	paper	0.60
40323531	correct	paper	0.60
mTOR	interacts_with	entity	0.50
IGF2BP2	inhibits	gene	0.50
MLCK	regulates	gene	0.50
ALZHEIMER	activates	gene	0.50
AMYLOID	activates	gene	0.50
TAU	activates	protein	0.50
EGFR	activates	gene	0.50
SENP1	activates	gene	0.50
ALZHEIMER	decreases_risk	gene	0.50
DOT1L	regulates	gene	0.50
SIRT6	inhibits	gene	0.50
TFEB	activates	protein	0.50
ACTB	activates	gene	0.50
Autophagy	activates	process	0.50
ULK1	activates	gene	0.50
SETX	activates	gene	0.50
BECN1	activates	gene	0.50
GABA	activates	gene	0.50
SQSTM1	activates	gene	0.50
SMN1	activates	gene	0.50
WIPI2	activates	gene	0.50
ALS4	activates	gene	0.50
ATG7	activates	protein	0.50
GABARAP	activates	protein	0.50
IRF1	activates	gene	0.50
NPM1	activates	gene	0.50
NLRC5	activates	gene	0.50
CIITA	activates	protein	0.50
CD33	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
microglia	associated_with	cell_type	0.50
INPP5D	associated_with	gene	0.50
SORL1	associated_with	gene	0.50
LRP1	expressed_in	gene	0.50
SEMA3F	expressed_in	gene	0.50
LRP5	expressed_in	gene	0.50
OMA1	inhibits	gene	0.50
STAT3	activates	gene	0.50
TRPM7	activates	gene	0.50

Targeting Hypotheses (8)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CHIP-mediated ubiquitination selectively targets oligomeric	0.590	protein biochemistry	Do chaperones selectively recognize path
CHIP E3 Ligase Enhancement to Target Synaptic Proteins for D	0.474	proteomics	Quantitative proteomics of the aging syn
CHIP-mediated K63-linked ubiquitination redirects oligomeric	0.380	protein biochemistry	Do chaperones selectively recognize path
CHIP-mediated K63-linked ubiquitination promotes autophagoso	0.380	protein biochemistry	Do chaperones selectively recognize path
HSP70 recognition of exposed β-sheet segments triggers CHIP-	0.380	protein biochemistry	Do chaperones selectively recognize path

Kinetic Threshold Model Predicts CHIP-Mediated Clearance Req	0.380	protein folding	Can chaperone enhancement approaches ove
Kinetic Threshold Model of Chaperone-CHIP Coupling: ATP Cycl	0.380	protein folding	Can chaperone enhancement approaches ove
Exposed amyloidogenic segments trigger CHIP-mediated oligome	0.380	protein biochemistry	Do chaperones selectively recognize path

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (4)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Hsp multichaperone complex buffers pathologically modified Tau. [PMID:35760815]	Unknown	Nat Commun	2022
Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid β and P-tau an [PMID:36195875]	Unknown	J Neuroinflammation	2022
Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S protea [PMID:20478262]	Unknown	Arch Biochem Biophys	2010
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. [PMID:14962978]	Unknown	Hum Mol Genet	2004

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHIP in their description or question text

Kinetic Threshold Model Predicts CHIP-Mediated Clearance Requirements for Preven

Score: 0.380 · protein folding · 2026-04-26

This hypothesis integrates kinetic modeling of chaperone disaggregation capacity with targeted enhancement of protein cl

Kinetic Threshold Model of Chaperone-CHIP Coupling: ATP Cycle Velocity Determine

Score: 0.380 · protein folding · 2026-04-27

This hypothesis proposes that the efficiency of pathological protein clearance is governed by the kinetic coupling betwe

Exposed amyloidogenic segments trigger CHIP-mediated oligomer-selective ubiquiti

Score: 0.380 · protein biochemistry · 2026-04-27

This hypothesis proposes that HSP70's recognition of exposed β-sheet propensity sequences in amyloidogenic proteins serv