disease

OBESITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OBESITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1984Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Disease Info

Associated Genes	ALZHEIMER, AMPK, BDNF, DEMENTIA, EGFR, FNDC5, GPR120, GSH
Therapeutic Agents	SEMAGLUTIDE, SPERMIDINE
KG Connections	405 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Pathway Diagram

graph TD
    OBESITY["OBESITY"] -->|"causes"| TUMOR["TUMOR"]
    style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    OBESITY["OBESITY"] -->|"exacerbates"| SENESCENCE["SENESCENCE"]
    style SENESCENCE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    OBESITY["OBESITY"] -->|"targets"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    OBESITY["OBESITY"] -.->|"inhibits"| STAT3["STAT3"]
    style STAT3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    OBESITY["OBESITY"] -->|"associated"| STROKE["STROKE"]
    style STROKE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    OBESITY["OBESITY"] -->|"interacts"| AUTOPHAGY["AUTOPHAGY"]
    style AUTOPHAGY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    OBESITY["OBESITY"] -->|"activates"| AMYLOID["AMYLOID"]
    style AMYLOID fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    CIRCADIAN_DISRUPTION["CIRCADIAN DISRUPTION"] -->|"associated"| OBESITY["OBESITY"]
    style CIRCADIAN_DISRUPTION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    GUT["GUT"] -->|"associated"| OBESITY["OBESITY"]
    style GUT fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    INFLAMMATION["INFLAMMATION"] -->|"associated"| OBESITY["OBESITY"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ADIPOSE_TISSUE_MACROPHAGES["ADIPOSE TISSUE MACROPHAGES"] -->|"associated"| OBESITY["OBESITY"]
    style ADIPOSE_TISSUE_MACROPHAGES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SEMAGLUTIDE["SEMAGLUTIDE"] -->|"treats"| OBESITY["OBESITY"]
    style SEMAGLUTIDE fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    style OBESITY fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (639)

Target	Relation	Type	Str
Insulin Resistance	activates	disease	1.00
Glycolysis	activates	pathway	1.00
Inflammation	activates	disease	1.00
Lipid Metabolism	activates	pathway	1.00
Als	associated_with	disease	1.00
Type 2 Diabetes	associated_with	disease	1.00
Microrna	regulates	pathway	1.00
Diabetes	regulates	disease	1.00
Als	activates	disease	1.00
Inflammation	associated_with	disease	1.00
Nf-Κb	inhibits	pathway	1.00
Als	regulates	disease	1.00
Mtor	activates	pathway	1.00
Nf-Κb	activates	pathway	1.00
Autophagy	activates	pathway	1.00
Insulin Resistance	associated_with	disease	1.00
Autophagy	regulates	pathway	1.00
Oxidative Stress	associated_with	pathway	1.00
Oxidative Stress	activates	pathway	1.00
Immune Response	activates	pathway	1.00
Lipid Metabolism	regulates	pathway	1.00
Diabetes	associated_with	disease	1.00
Lipid Metabolism	associated_with	pathway	1.00
Oxidative Phosphorylation	activates	pathway	1.00
Type 2 Diabetes	regulates	disease	0.95
Als	therapeutic_target	disease	0.95
Diabetes	activates	disease	0.95
Inflammation	inhibits	disease	0.95
Lysosomal Dysfunction	causes	mechanism	0.95
Memory Dysfunction	causes	phenotype	0.95
MAFLD	risk_factor_for	disease	0.95
Cognitive Decline	causes	phenotype	0.95
Cardiovascular Ageing	associated_with	process	0.95
Type 2 Diabetes	therapeutic_target	disease	0.95
Autolysosomal Dysfunction	causes	process	0.95
Breast Cancer	risk_factor_for	disease	0.95
Cardiovascular Disease	risk_factor_for	disease	0.90
IL-6	causes	protein	0.90
Hippocampal Neurogenesis	associated_with	process	0.90
Neuroinflammation	causes	process	0.90
neural stem cells	affects	cell_type	0.90
Depression	associated_with	disease	0.90
Alzheimer's Disease	associated_with	disease	0.90
Synaptogenesis	associated_with	process	0.90
Cellular Senescence	associated_with	process	0.90
OXIDATIVE STRESS	causes	process	0.90
Alzheimer'S Disease	risk_factor_for	disease	0.90
Apoptosis	associated_with	pathway	0.90
Epigenetic	therapeutic_target	pathway	0.90
Cholesterol	regulates	pathway	0.90

Incoming (1345)

Source	Relation	Type	Str
Als	regulates	disease	1.00
IL-6	activates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
Cancer	associated_with	disease	1.00
SIRT1	activates	gene	1.00
MITOCHONDRIA	activates	gene	1.00
NF-ΚB	activates	gene	1.00
GENES	regulates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
CANCER	associated_with	gene	1.00
Diabetes	activates	disease	1.00
ATP	activates	gene	1.00
AUTOPHAGY	regulates	gene	1.00
Metabolic Syndrome	associated_with	disease	1.00
CYTOKINES	activates	gene	1.00
INSULIN RESISTANCE	associated_with	gene	1.00
Als	associated_with	disease	1.00
INFLAMMATION	associated_with	gene	1.00
OVERVIEW	associated_with	gene	1.00
Diabetes	associated_with	disease	1.00
CYTOKINES	regulates	gene	1.00
Cardiovascular	associated_with	disease	1.00
Als	activates	disease	1.00
NEUROINFLAMMATION	activates	gene	1.00
GENES	activates	gene	1.00
ALZHEIMER	associated_with	gene	1.00
AGING	regulates	gene	1.00
Inflammation	activates	disease	1.00
Als	therapeutic_target	disease	1.00
INFLAMMATION	causes	gene	1.00
MICROGLIA	activates	gene	1.00
MIRNAS	regulates	gene	1.00
Cancer	activates	disease	1.00
Hypertension	associated_with	disease	1.00
AKT	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
Tumor	activates	disease	1.00
INFLAMMATION	inhibits	gene	1.00
PI3K	activates	gene	1.00
CANCER	activates	gene	1.00
INFLAMMATION	regulates	gene	1.00
CANCER	therapeutic_target	gene	1.00
AUTOPHAGY	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
INSULIN RESISTANCE	activates	gene	1.00
OXIDATIVE STRESS	associated_with	gene	1.00
DIABETES MELLITUS	associated_with	gene	1.00
MICRORNAS	regulates	gene	1.00
AMPK	activates	gene	1.00
NF-ΚB	inhibits	gene	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning OBESITY in their description or question text

No additional research found