gene

SLC1A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC1A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

153Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

SLC1A2 (EAAT2) is the primary glutamate transporter in the brain, responsible for clearing glutamate from the synaptic cleft. Dysfunction of SLC1A2 is strongly implicated in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis throu

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🧬 Gene Info

Gene Symbol	SLC1A2
Full Name	Solute Carrier Family 1 Member 2 (EAAT2)
Aliases	EAAT2
Chromosome	11p13
Protein Type	Gene
Function	encodes a protein of 574 amino acids with a molecular weight of approximately 66 kDa.
Primary Expression	astrocytes surrounding synapses, where it plays a critical role in synaptic homeostasis and neuroprotection
Molecular Weight	66 kDa
Amino Acids	574 aa
Exons	19
Pathways	Tdp-43, oxidative stress response, synaptic plasticity, unfolded protein response
GeneCards	SLC1A2
Human Protein Atlas	SLC1A2
Astrocytes	The primary cellular expression site, particularly perisynaptic astrocyte processes
Cerebral cortex	High expression in layers II-IV
Associated Diseases	ADHD, ALS, Alzheimer, Alzheimer's disease, anxiety
Interactions	AND, ANXIETY, APOE, App, AQP4, ASTROCYTE
KG Connections	153 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SLC1A2 — Solute Carrier Family 1 Member 2 (EAAT2)

gene · 1148 words

→

SLC1A2 Protein — EAAT2/GLT-1

protein · 644 words

→

Pathway Diagram

graph TD
    SLC1A2["SLC1A2"]
    Dementia{"Dementia"}
    SLC1A2 -->|"activates"| Dementia
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    SLC1A2 -->|"activates"| Frontotemporal_Dementia
    Neurodegeneration{"Neurodegeneration"}
    SLC1A2 -->|"activates"| Neurodegeneration
    NEURODEGENERATION["NEURODEGENERATION"]
    SLC1A2 -->|"activates"| NEURODEGENERATION
    ASTROCYTES["ASTROCYTES"]
    SLC1A2 -->|"activates"| ASTROCYTES
    GJA1["GJA1"]
    GJA1 -->|"activates"| SLC1A2
    PROGRANULIN["PROGRANULIN"]
    PROGRANULIN -->|"activates"| SLC1A2
    FTLD["FTLD"]
    FTLD -->|"activates"| SLC1A2
    AQP4["AQP4"]
    AQP4 -->|"activates"| SLC1A2
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"activates"| SLC1A2
    GRN["GRN"]
    GRN -->|"activates"| SLC1A2
    AND["AND"]
    AND -->|"activates"| SLC1A2
    NEURON["NEURON"]
    NEURON -->|"activates"| SLC1A2
    APOE["APOE"]
    APOE -->|"activates"| SLC1A2
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"activates"| SLC1A2

Outgoing (80)

Target	Relation	Type	Str
ASTROCYTES	expressed_in	cell_type	0.95
ALZHEIMER'S DISEASE	associated_with	disease	0.90
PARKINSON'S DISEASE	associated_with	disease	0.90
Signal Transmission	involved_in	process	0.90
Synaptic Degeneration	suppresses	phenotype	0.85
Glutamate Transport	mediates	process	0.80
Neurotransmitter receptor localization	regulates	process	0.80
Als	activates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Anxiety	activates	disease	0.65
ALS	activates	disease	0.65
Dementia	activates	disease	0.65
Tauopathy	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Proteasome	interacts_with	pathway	0.60
Neurogenesis	interacts_with	pathway	0.60
SYNPO	implicated_in	gene	0.60
Alzheimer's disease	associated_with	disease	0.60
TUBB2B	implicated_in	gene	0.60
Parkinson's disease	associated_with	disease	0.60
dementia	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
ALS	associated_with	disease	0.60
ASTROCYTE	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
neurodegeneration	associated_with	disease	0.60
frontotemporal	associated_with	disease	0.60
PSP	interacts_with	gene	0.60
ASTROCYTES	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
SLC1A3	associated_with	gene	0.60
seizures	associated_with	phenotype	0.60
febrile seizures	implicated_in	disease	0.60
Fragile X Syndrome	implicated_in	disease	0.60
ADHD	associated_with	disease	0.60
anxiety	associated_with	phenotype	0.60
PROGRANULIN	activates	gene	0.60
AQP4	activates	gene	0.60
GRN	activates	gene	0.60
GJA1	activates	gene	0.60
APOE	activates	gene	0.60
TDP-43	activates	gene	0.60
Stem Cell	activates	cell_type	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60

Incoming (73)

Source	Relation	Type	Str
YY1	downregulates	gene	0.95
h-019c56c1	targets	hypothesis	0.90
ALKBH5	regulates	protein	0.90
GFAP	markers	gene	0.70
RNA	implicated_in	gene	0.60
GABA	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
FMRP	regulates	protein	0.60
ASTROCYTE	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEURON	associated_with	gene	0.60
ASTROCYTE	markers	cell_type	0.60
GFAP	transports	gene	0.60
GLUTAMATERGIC	associated_with	cell_type	0.60
GRN	co_discussed	gene	0.60
NF-κB	regulates	protein	0.60
FTLD	activates	gene	0.60
NEURON	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
CORTEX	activates	brain_region	0.60
FRONTAL	activates	brain_region	0.60
ASTROCYTE	transports	cell_type	0.60
NEURON	transports	cell_type	0.60
FTLD	implicated_in	gene	0.60
DEMENTIA	activates	gene	0.60
MAPK	co_discussed	gene	0.60
NEUROINFLAMMATION	co_discussed	pathway	0.60
OXIDATIVE STRESS	co_discussed	pathway	0.60
PROGRANULIN	activates	gene	0.60
APOE	activates	gene	0.60
GRN	activates	gene	0.60
AQP4	activates	gene	0.60
AD	transports	gene	0.60
AND	activates	gene	0.60
GJA1	activates	gene	0.60
GABA	associated_with	gene	0.60
ASTROCYTES	activates	gene	0.60
ANXIETY	activates	gene	0.60
COMT	co_discussed	gene	0.60
GRIN2A	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
Manganese	inhibits	chemical	0.60
YY1	inhibits	protein	0.60
Crocin	activates	chemical	0.60
TDP-43	activates	gene	0.60
APOE	inhibits	gene	0.60
AQP4	inhibits	gene	0.60
TAU	transports	gene	0.60
PSMB7	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.761

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Cell-type specific expression patterns of neurodegeneration genes in SEA-AD

closed · Rounds: 3 · Score: 0.68 · 2026-04-02

Related Research

Hypotheses and analyses mentioning SLC1A2 in their description or question text

No additional research found