gene 622 words KG: YY1
Contents

YY1 — Yin Yang 1

🧬 Gene Info
Gene SymbolYY1
Full NameYin Yang 1
Chromosome14q32.31
Protein TypeTranscription Factor
FunctionThe YY1 gene encodes Yin Yang 1, a ubiquitously expressed zinc-finger transcription factor.
Primary ExpressionUbiquitous, Brain, Muscle, Heart
PathwaysCgas-Sting, Mtor, Oxidative Phosphorylation
UniProt IDQ08050
NCBI Gene ID7528
Ensembl IDENSG00000100811
OMIM400713
GeneCardsYY1
Human Protein AtlasYY1
Associated DiseasesAging, Als, Alzheimer, Ataxia, Dystonia
InteractionsAGING, AKT3, ALZHEIMER, ALZHEIMER'S DISEASE, ANG, App
KG Connections219 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (15)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (13)

Astrocytes
cell · KG edge: activates
Astrocytes
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_with
ADNP Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

YY1 associated_with HDAC2
YY1 associated_with LAMP1
YY1 associated_with ADNP
YY1 associated_with BECN1
YY1 associated_with SIRT1
YY1 associated_with LC3
YY1 interacts_with USP7
YY1 activates EGFR
TREM2 expressed_in YY1
GPX4 inhibits YY1

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