gene

IDO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IDO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections

0Hypotheses

0Analyses

50Outgoing

25Incoming

0Experiments

0Debates

Summary

IDO1 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, expressed in. Associated with Als, Alzheimer, Autoimmune. Connected to 48 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IDO1
Full Name	Indoleamine 2,3-Dioxygenase 1
Chromosome	8p11.21
Function	is a gene on chromosome 8p11.
Primary Expression	Microglia, astrocytes, macrophages, dendritic cells
Molecular Weight	45 kDa
Amino Acids	403 aa
Exons	10
Pathways	Glycolysis, blood-brain barrier, ferroptosis, oxidative stress response, synaptic plasticity
UniProt ID	P14902
NCBI Gene ID	3620
Ensembl ID	ENSG00000131203
OMIM	147435
GeneCards	IDO1
Human Protein Atlas	IDO1
Associated Diseases	cancer, Infection, neuroinflammation
Interactions	AHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ASTROCYTE
KG Connections	89 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IDO1 — AlphaFold P14902 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IDO1 — Indoleamine 2,3-Dioxygenase 1

gene · 1479 words

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IDO1 Protein

protein · 1244 words

→

Pathway Diagram

graph TD
    IDO1["IDO1"]
    tryptophan["tryptophan"]
    IDO1 -->|"catalyzes"| tryptophan
    kynurenine["kynurenine"]
    IDO1 -->|"produces"| kynurenine
    Cancer{"Cancer"}
    IDO1 -->|"associated with"| Cancer
    Ms{"Ms"}
    IDO1 -->|"activates"| Ms
    Depression{"Depression"}
    IDO1 -->|"activates"| Depression
    Als{"Als"}
    IDO1 -->|"inhibits"| Als
    IDO1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    IDO1 -->|"inhibits"| Tumor
    Ferroptosis(["Ferroptosis"])
    IDO1 -->|"expressed in"| Ferroptosis
    SLC7A11["SLC7A11"]
    IDO1 -->|"expressed in"| SLC7A11
    GBA["GBA"]
    IDO1 -->|"activates"| GBA
    ENDOSOMES["ENDOSOMES"]
    IDO1 -->|"inhibits"| ENDOSOMES
    SLC7A11 -->|"expressed in"| IDO1
    TPH2["TPH2"]
    TPH2 -->|"activates"| IDO1
    GUT_BRAIN_AXIS["GUT-BRAIN AXIS"]
    GUT_BRAIN_AXIS -->|"activates"| IDO1
    SRC["SRC"]
    SRC -->|"inhibits"| IDO1
    PI3K["PI3K"]
    PI3K -->|"inhibits"| IDO1
    AND["AND"]
    AND -->|"inhibits"| IDO1
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"expressed in"| IDO1
    style IDO1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (64)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.75
Als	inhibits	disease	0.75
tryptophan	catalyzes	drug	0.72
kynurenine	produces	drug	0.72
Inflammation	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Autoimmune	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	inhibits	disease	0.65
Atherosclerosis	activates	disease	0.65
Ms	activates	disease	0.65
Depression	activates	disease	0.65
Tumor	inhibits	disease	0.65
ENDOSOMES	inhibits	gene	0.60
Rb	activates	protein	0.60
Pi3K	inhibits	pathway	0.60
Tgf-Β	inhibits	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
Rb	associated_with	protein	0.60
CANCER	inhibits	gene	0.60
YY1	activates	gene	0.60
IRF1	activates	gene	0.60
SLC7A11	inhibits	entity	0.60
Ferroptosis	expressed_in	pathway	0.60
FERROPTOSIS	expressed_in	gene	0.60
MICROGLIA	activates	gene	0.60
Immunotherapy	inhibits	pathway	0.60
LDL	activates	gene	0.60
Macrophage	activates	cell_type	0.60
Interleukin	activates	protein	0.60
CANCER	associated_with	gene	0.60
Glycolysis	activates	pathway	0.60
Long-Term Potentiation	inhibits	pathway	0.60
AND	inhibits	gene	0.60
INFLAMMATION	activates	gene	0.60
hippocampus	expressed_in	brain_region	0.60
NAD	associated_with	gene	0.60
SLC7A11	expressed_in	gene	0.60
ferroptosis	participates_in	pathway	0.60
AND	activates	gene	0.60
AHR	activates	gene	0.60
AMYLOID	activates	gene	0.60
Astrocyte	inhibits	cell_type	0.60
Neuron	inhibits	cell_type	0.60
astrocytes	expressed_in	cell_type	0.60
synaptic plasticity	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
GBA	activates	gene	0.60

Incoming (25)

Source	Relation	Type	Str
NAD	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
GENES	activates	gene	0.60
CCL5	activates	gene	0.60
LDL	activates	gene	0.60
STAT3	activates	gene	0.60
AHR	activates	entity	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
PI3K	inhibits	gene	0.60
CANCER	therapeutic_target	gene	0.60
TPH2	activates	gene	0.60
SRC	inhibits	gene	0.60
GUT-BRAIN AXIS	activates	gene	0.60
SLC7A11	expressed_in	gene	0.60
TAU	activates	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
CANCER	inhibits	gene	0.60
ASTROCYTE	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
CANCER	associated_with	entity	0.60
SLC7A11	inhibits	gene	0.50
FERROPTOSIS	inhibits	process	0.35
ATHEROSCLEROSIS	activates	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IDO1 in their description or question text

No additional research found