gene 1,477 words KG: TTR
Contents

TTR — Transthyretin

🧬 Gene Info
Gene SymbolTTR
Full NameTransthyretin
Chromosome18q12.1.
FunctionUnder normal conditions, TTR functions as
Primary ExpressionLiver, Choroid plexus, Retinal pigment epithelium, Pancreas
Molecular Weight55 kDa
Amino Acids127 aa
UniProt IDP02766
NCBI Gene ID7276
Ensembl IDENSG00000118271
OMIM176300
GeneCardsTTR
Human Protein AtlasTTR
Associated DiseasesAls, hereditary polyneuropathies, Hereditary Polyneuropathy, Ms
InteractionsAKT1, ALZHEIMER, AMYLOID, APP, AQP1, CYTOKINES
KG Connections63 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (2)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Osmotic Gradient Restoration via Selective AQP1 Enhancement
Score: 0.68

Related Analyses (2)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

cGAS-STING Pathway Validation Study in Parkinson's Disease
clinical · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (15)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
Genes
index · KG edge: therapeutic_target
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: interacts_with
AQP1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

CAPN1 therapeutic_target TTR
TTR therapeutic_target LGALS3
TTR therapeutic_target CTSD
TTR therapeutic_target GRB2
TTR therapeutic_target TLR4
TTR therapeutic_target NFE2L2
TTR therapeutic_target RPS6KA1
TTR therapeutic_target HIF1A
TTR therapeutic_target GRIN1
TTR therapeutic_target ADAM10

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