gene 533 words KG: TRPV1
Contents

TRPV1 Gene

🧬 Gene Info
Gene SymbolTRPV1
Full NameTransient Receptor Potential Cation Channel Subfamily V Member 1
Chromosome17p13.2
Protein TypeProtein
FunctionTRPV1 is a capsaicin-activated ion channel that responds to heat and pain stimuli.
Primary Expressionsensory neurons (dorsal root ganglion, trigeminal ganglion), where it functions as a polymodal nociceptor activated by[@caterina2
PathwaysAutophagy
UniProt ID[Q9Y5Q1](https://www.uniprot.org/uniprotkb/Q9Y5Q1/entry)
GeneCardsTRPV1
Human Protein AtlasTRPV1
Associated DiseasesCancer, Ovarian Cancer
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AND, APOE3, APOE4, APOPTOSIS
KG Connections235 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Extracellular Matrix Stiffness Modulation
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58

Related Analyses (7)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (10)

blarcamesine-axon
clinical_trial · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: activates
AKT1 Gene
gene · KG edge: therapeutic_target
ASCL1 Gene
gene · KG edge: regulates
CACNA1B Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PIEZO1 associated_with TRPV1
KCNK2 associated_with TRPV1
SCN5A associated_with TRPV1
TRPM7 associated_with TRPV1
SCN1A associated_with TRPV1
TRPV4 associated_with TRPV1
CACNA1B associated_with TRPV1
SCNN1A associated_with TRPV1
CFTR associated_with TRPV1
PIEZO2 associated_with TRPV1

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