gene

LHX6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LHX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

7Outgoing

7Incoming

0Experiments

0Debates

Summary

LHX6 encodes a LIM-type homeobox transcription factor critical for GABAergic interneuron development, cortical circuit formation, synaptic inhibition, and cognitive function, with emerging roles in neurodegenerative diseases including Alzheimer's and Parkinson's.

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🧬 Gene Info

Gene Symbol	LHX6
Full Name	LIM Homeobox 6
Chromosome	9q33
Protein Type	Transcription Factor
Function	encodes a LIM-type homeobox transcription factor that plays a fundamental role in the development of GABAergic inhibitory interneurons in the mammalian forebrain.
Primary Expression	specific interneuron populations, where it maintains aspects of interneuron identity and function
Molecular Weight	43.8 kDa
Amino Acids	406 aa
Pathways	Shh, BMP, Wnt
UniProt ID	Q9R0E3
NCBI Gene ID	26468
Ensembl ID	ENSG00000106852
OMIM	608139
GeneCards	LHX6
Human Protein Atlas	LHX6
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LHX6 — AlphaFold Q9R0E3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LHX6 — LIM Homeobox 6

gene · 1696 words

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LHX6-Positive Neurons

cell · 935 words

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Pathway Diagram

graph TD
    LHX6["LHX6"]
    Als{"Als"}
    LHX6 -->|"regulates"| Als
    Diabetes{"Diabetes"}
    LHX6 -->|"regulates"| Diabetes
    Neuropathy{"Neuropathy"}
    LHX6 -->|"regulates"| Neuropathy
    IL_6["IL-6"]
    LHX6 -->|"regulates"| IL_6
    Neuron["Neuron"]
    LHX6 -->|"regulates"| Neuron
    Il_1("Il-1")
    LHX6 -->|"regulates"| Il_1
    IL_1["IL-1"]
    IL_1 -->|"regulates"| LHX6
    TRPV1["TRPV1"]
    TRPV1 -->|"regulates"| LHX6
    RNA["RNA"]
    RNA -->|"regulates"| LHX6
    ASCL1["ASCL1"]
    ASCL1 -->|"regulates"| LHX6
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"regulates"| LHX6
    neurodegeneration["neurodegeneration"]
    LHX6 -->|"implicated_in"| neurodegeneration

Outgoing (7)

Target	Relation	Type	Str
Neuropathy	regulates	disease	0.65
Als	regulates	disease	0.65
Diabetes	regulates	disease	0.65
IL-6	regulates	gene	0.60
Neuron	regulates	cell_type	0.60
Il-1	regulates	protein	0.60
neurons	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
genes-lhx6	linked_to	wiki	1.00
IL-1	regulates	gene	0.60
RNA	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
TRPV1	regulates	gene	0.60
ASCL1	regulates	gene	0.60
DLX1	associated_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LHX6 in their description or question text

No additional research found