Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Glucocorticoid receptor / stress response: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Multi-Modal Stress Response Harmonization | 0.756 | neurodegeneration | Digital biomarkers and AI-driven early d |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Gestational haloperidol exposure effects on hippocampal gene expressio | validation | schizophrenia | 0.900 | 0.00 | pregnant mice and offspring | proposed | N/A |
| Dual-luciferase assay for miR-137-3p target validation | exploratory | schizophrenia | 0.800 | 0.00 | cell culture system with dual- | proposed | N/A |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $180,000 |
| Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Animal Model Comparison for Neurodegenerative Disease Therapeutics | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Experiment: Autoimmune Hypothesis Testing in AD | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Index | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
| N-of-1 Clinical Trial Design for CBS/PSP | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Scoring Methodology | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Traumatic Brain Injury and Alzheimer's Disease Relationship | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $3,000,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Methylation of HPA axis related genes in men with hypersexual disorder. [PMID:28319850] | Jokinen J, Boström AE, Chatzittofis A, C | Psychoneuroendocrinology | 2017 | 1 |
| Development of alopecia areata is associated with higher central and peripheral [PMID:19020552] | Zhang X, Yu M, Yu W, Weinberg J, Shapiro | J Invest Dermatol | 2009 | 1 |
| Cytokine associated neuroinflammation in Parkinson's disease: Molecular pathways [PMID:41512596] | ["Dhapola R", "Kumari S", "Sharma P", "P | Cytokine & growth factor revie | 2026 | 0 |
| Neurobiological and therapeutic landmarks of depression associated with Alzheime [PMID:40529210] | ["Untu I", "Davidson M", "Stanciu G", "R | Frontiers in aging neuroscienc | 2025 | 0 |
| Neurobiological mechanisms and recent advances in drug-based therapeutics in dep [PMID:41205901] | ["Ahmadnia H", "Abdollahzadeh R", "Hatam | Neuroscience | 2025 | 0 |
| Multi-Target Protective Effects of β-Caryophyllene (BCP) at the Intersection of [PMID:40649806] | ["Ricardi C", "Mazzierli A", "Guglielmo | International journal of molec | 2025 | 0 |
| A novel multi-target compound mitigates amyloid plaques, synaptic deficits, and [PMID:40770166] | ["Lee Y", "Han S", "Lee J", "Cho Y", "Ki | Archives of pharmacal research | 2025 | 0 |
| Beyond Pulmonary Vein Reconnection: Exploring the Dynamic Pathophysiology of Atr [PMID:40363950] | ["Vlachakis P", "Theofilis P", "Apostolo | Journal of clinical medicine | 2025 | 0 |
| Decoding Parkinson's Disease: The interplay of cell death pathways, oxidative st [PMID:40712453] | ["Liu T", "Kong X", "Qiao J", "Wei J"] | Redox biology | 2025 | 0 |
| Glucocorticoid treatment and adrenal suppression in children: current view and o [PMID:39352628] | ["Improda N", "Chioma L", "Capalbo D", " | Journal of endocrinological in | 2025 | 0 |
| Sex Differences in Stress Response: Classical Mechanisms and Beyond. [PMID:37855285] | ["Hodes G", "Bangasser D", "Sotiropoulos | Current neuropharmacology | 2024 | 0 |
| Heat exposure intervention, anxiety level, and multi-omic profiles: A randomized [PMID:37871510] | ["Fang W", "Liu L", "Yin B", "Ke L", "Su | Environment international | 2023 | 0 |
| Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using Pa [PMID:35837482] | Pun FW, Liu BHM, Long X | Front Aging Neurosci | 2022 | 0 |
| Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiol [PMID:29966221] | ["Sevilla L", "P\u00e9rez P"] | International journal of molec | 2018 | 0 |
| The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the sele [PMID:30215534] | ["Mylka V", "Deckers J", "Ratman D", "De | Autophagy | 2018 | 0 |
| Novel multi-target directed ligand-based strategies for reducing neuroinflammati [PMID:29940242] | ["Wenzel T", "Klegeris A"] | Life sciences | 2018 | 0 |
| Hippocampal damage mediated by corticosteroids--a neuropsychiatric research chal [PMID:11824844] | ["H\u00f6schl C", "Hajek T"] | European archives of psychiatr | 2001 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning Glucocorticoid receptor / stress response in their description or question text
No additional research found