protein

TRPM8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRPM8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

27Outgoing

20Incoming

0Experiments

0Debates

Summary

TRPM8 is a protein involved in neurodegeneration research. Key relationships include: expressed in, upregulates, implicated in. Associated with ALS, Als, Inflammation. Connected to 20 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	TRPM8
Full Name	Transient Receptor Potential Cation Channel Subfamily M Member 8
Chromosome	2q37
Protein Type	Receptor
Function	TRPM8 encodes the Transient Receptor Potential Melastatin 8 channel, a non-selective calcium-permeable cation channel activated by cold temperatures (below 25°C), menthol, and other cooling agents.
Primary Expression	a subset of sensory neurons (cold-sensitive dorsal root ganglion and trigeminal ganglion neurons) and in some central neurons
Molecular Weight	110 kDa
Amino Acids	1104 aa
Pathways	Adaptive Immunity
UniProt ID	[Q7Z2W7](https://www.uniprot.org/uniprot/Q7Z2W7)
Ensembl ID	ENSG00000164189
OMIM	607687
GeneCards	TRPM8
Human Protein Atlas	TRPM8
Associated Diseases	neurodegeneration
Interactions	TAC1, TNFA, TRPA1, WNT3A
KG Connections	47 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRPM8["TRPM8"]
    Periodontal_Ligament_Cells["Periodontal Ligament Cells"]
    TRPM8 -->|"expressed in"| Periodontal_Ligament_Cells
    Als{"Als"}
    TRPM8 -->|"expressed in"| Als
    Ms{"Ms"}
    TRPM8 -->|"expressed in"| Ms
    Inflammation{"Inflammation"}
    TRPM8 -->|"expressed in"| Inflammation
    ALS{"ALS"}
    TRPM8 -->|"expressed in"| ALS
    KCNK2["KCNK2"]
    TRPM8 -->|"expressed in"| KCNK2
    TNF["TNF"]
    TRPM8 -->|"expressed in"| TNF
    TNF__["TNF-Alpha"]
    TRPM8 -->|"expressed in"| TNF__
    INFLAMMATION["INFLAMMATION"]
    TRPM8 -->|"expressed in"| INFLAMMATION
    TRPA1["TRPA1"]
    TRPM8 -->|"expressed in"| TRPA1
    T_Cell["T Cell"]
    TRPM8 -->|"expressed in"| T_Cell
    neurodegeneration["neurodegeneration"]
    TRPM8 -->|"implicated in"| neurodegeneration
    TNF__ -->|"upregulates"| TRPM8
    TNFA["TNFA"]
    TNFA -->|"activates"| TRPM8
    PIEZO1["PIEZO1"]
    PIEZO1 -->|"expressed in"| TRPM8
    KCNK2 -->|"expressed in"| TRPM8
    TNF -->|"expressed in"| TRPM8
    TRPA1 -->|"expressed in"| TRPM8
    TNF__ -->|"expressed in"| TRPM8
    INFLAMMATION -->|"expressed in"| TRPM8
    AND["AND"]
    AND -->|"expressed in"| TRPM8
    style TRPM8 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (27)

Target	Relation	Type	Str
MECHANOTRANSDUCTION	involved_in	entity	0.90
orthodontic tooth movement	involved_in	process	0.85
Periodontal Ligament Cell	expressed_in	cell_type	0.85
Periodontal Ligament Cells	expressed_in	cell_type	0.85
Ms	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
neurons	expressed_in	cell_type	0.60
apoptosis pathway	participates_in	pathway	0.60
KCNK2	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
TRPA1	expressed_in	gene	0.60
PIEZO1	expressed_in	gene	0.60
WNT3A	activates	gene	0.60
Macrophage	inhibits	cell_type	0.60
AND	regulates	gene	0.60
Adaptive Immunity	regulates	pathway	0.60
TNF-Α	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
PIEZO	expressed_in	gene	0.60
PKD2	expressed_in	gene	0.60
T Cell	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55
TNF-α	activates	concept	0.50

Incoming (20)

Source	Relation	Type	Str
TNF-α	upregulates	protein	0.95
TNF	modulates	entity	0.90
Frostbite Injury	upregulates	disease	0.90
TNF-Α	upregulates	protein	0.85
TNF	upregulates	entity	0.85
TNF-Α	modulates	protein	0.80
TNFA	activates	protein	0.64
PIEZO1	expressed_in	gene	0.60
PKD2	expressed_in	gene	0.60
TRPA1	regulates	entity	0.60
TRPA1	expressed_in	gene	0.60
TAC1	activates	gene	0.60
TNF-Α	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
KCNK2	expressed_in	gene	0.60
PIEZO	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
TRPA1	activates	gene	0.50
GENES	co_discussed	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRPM8 in their description or question text

No additional research found