| Gene Symbol | TNFAIP3 |
| Full Name | TNF Alpha Induced Protein 3 (A20) |
| Chromosome | 6q23.3 |
| Function | The NF-κB pathway controls the expression of inflammatory cytokines, chemokines, and survival genes. |
| Primary Expression | microglia, astrocytes, and neurons, where it controls neur |
| Molecular Weight | 90 kDa |
| Amino Acids | 790 aa |
| Exons | 9 |
| Pathways | NF-κB, NF-κB signaling |
| UniProt ID | [P21579](https://www.uniprot.org/uniprot/P21579) |
| Ensembl ID | ENSG00000118503 |
| OMIM | 191163 |
| GeneCards | TNFAIP3 |
| Human Protein Atlas | TNFAIP3 |
| Deubiquitinase (DUB) activity | Removes ubiquitin chains from signaling molecules (TRAF6, RIPK1, NEMO) |
| Associated Diseases | Als, Ms |
| Interactions | ASTROCYTES, ATXN2, CGAS, CGAS-STING, Cytokine, CYTOKINES |
| KG Connections | 86 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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