gene

PRDX3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

97Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

0Experiments

0Debates

Summary

Page for PRDX3 — Peroxiredoxin 3

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🧬 Gene Info

Gene Symbol	PRDX3
Full Name	Peroxiredoxin 3
Chromosome	10q26.11
Function	is a mitochondrial member of the peroxiredoxin family of antioxidant enzymes that specifically reduces hydrogen peroxide (H₂O₂) and organic hydroperoxides[@rhee2001].
Exons	7
Pathways	senescence
Ensembl ID	ENSG00000115651
GeneCards	PRDX3
Human Protein Atlas	PRDX3
Catalytic cysteine (Cys47)	Peroxide-reducing active site
Resolving cysteine (Cys127)	Forms disulfide during catalytic cycle
TPx_2 domain	Characteristic of typical 2-Cys peroxiredoxins
Peroxide reduction	2-Cys catalytic mechanism reducing H₂O₂ to H₂O
Redox signaling regulation	Controls localized H₂O₂ concentrations
Protection of mitochondrial proteins	Prevents oxidative damage to respiratory chain components[@li2007]
Associated Diseases	Als, Alzheimer
Interactions	Actin, ALZHEIMER, AND, APOE, APP, BLM
KG Connections	97 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PRDX3 — Peroxiredoxin 3

gene · 807 words

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PRDX3 Protein

protein · 613 words

→

Pathway Diagram

graph TD
    PRDX3["PRDX3"]
    Carcinoma{"Carcinoma"}
    PRDX3 -->|"inhibits"| Carcinoma
    Ms{"Ms"}
    PRDX3 -->|"inhibits"| Ms
    Tumor{"Tumor"}
    PRDX3 -->|"contributes to"| Tumor
    SOD2["SOD2"]
    PRDX3 -->|"contributes to"| SOD2
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    PRDX3 -->|"contributes to"| OXIDATIVE_STRESS
    Oxidative_Stress(["Oxidative Stress"])
    PRDX3 -->|"contributes to"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    PRDX3 -->|"implicated in"| neurodegeneration
    COX5A["COX5A"]
    COX5A -->|"contributes to"| PRDX3
    PRDX6["PRDX6"]
    PRDX6 -->|"contributes to"| PRDX3
    style PRDX3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (64)

Target	Relation	Type	Str
senescence of alveolar epithelial cells	inhibits	process	0.80
Fibrosis	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Senescence	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Tumor	contributes_to	disease	0.65
Carcinoma	inhibits	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
APOE	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	associated_with	gene	0.60
AND	inhibits	gene	0.60
Igf	associated_with	protein	0.60
APP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
IDS	associated_with	gene	0.60
BLM	inhibits	gene	0.60
Actin	activates	protein	0.60
SOD2	contributes_to	gene	0.60
YAP1	inhibits	gene	0.60
Epithelial	inhibits	cell_type	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
Rb	inhibits	protein	0.60
SMARCB1	interacts_with	gene	0.60
SYNE2	interacts_with	gene	0.60
TMEM59	interacts_with	gene	0.60
OXIDATIVE STRESS	contributes_to	gene	0.60
Oxidative Stress	contributes_to	pathway	0.60
SYNE2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
Ras	inhibits	protein	0.60
senescence	regulates	process	0.60
SMARCB1	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
Epithelial Cell	expressed_in	cell_type	0.55
YAP1	activates	gene	0.50
TEAD1	activates	gene	0.50
FIBROSIS	inhibits	disease	0.50
Pulmonary Fibrosis	inhibits	disease	0.50

Incoming (33)

Source	Relation	Type	Str
COPA	interacts_with	gene	0.60
BLM	inhibits	gene	0.60
TEAD1	activates	gene	0.60
TMEM59	associated_with	gene	0.60
APOE	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
COX5A	contributes_to	gene	0.60
PRDX6	contributes_to	gene	0.60
IDS	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
COPA	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
APP	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
APP	interacts_with	gene	0.60
CALB1	interacts_with	gene	0.60
CCT4	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
APOE	interacts_with	gene	0.50
SYNE2	interacts_with	gene	0.50
SMARCB1	interacts_with	gene	0.50
TMEM59	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRDX3 in their description or question text

No additional research found