gene

STXBP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STXBP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

31Outgoing

34Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	STXBP3
Chromosome	19p13.3
Function	is a member of the STXBP (Syntaxin Binding Protein) family and belongs to the SM (Sec1/Munc18) protein family.
Subcellular Localization	## Normal Biological Functions
Molecular Weight	66 kDa
Amino Acids	594 aa
Exons	16
GeneCards	STXBP3
Human Protein Atlas	STXBP3
Phosphorylation	Serine/threonine phosphorylation modulates syntaxin binding
Palmitoylation	Affects membrane association
Ubiquitination	Targets STXBP3 for degradation
Sumoylation	Alters subcellular localization
Associated Diseases	Als, Alzheimer
Interactions	ALZHEIMER, APOE, APP, CALB1, CCT4, COPA
KG Connections	65 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

STXBP3 Gene

gene · 2450 words

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Pathway Diagram

graph TD
    STXBP3["STXBP3"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    RNF14["RNF14"]
    IDS["IDS"]
    SYNCRIP["SYNCRIP"]
    SSBP1["SSBP1"]
    PRDX3["PRDX3"]
    APP["APP"]
    ALZHEIMER["ALZHEIMER"]
    APOE["APOE"]
    SYNE2["SYNE2"]
    SMARCB1["SMARCB1"]
    ULK2["ULK2"]
    TMEM59["TMEM59"]
    SFPQ["SFPQ"]
    CCT4["CCT4"]
    CALB1["CALB1"]
    SORL1["SORL1"]
    IGF2R["IGF2R"]
    COPA["COPA"]
    STXBP3 -.-|"associated"| Alzheimer
    STXBP3 -.-|"associated"| Als
    STXBP3 -.-|"associated"| RNF14
    IDS -.-|"associated"| STXBP3
    SYNCRIP -.-|"associated"| STXBP3
    SSBP1 -.-|"associated"| STXBP3
    PRDX3 -.-|"associated"| STXBP3
    APP -.-|"associated"| STXBP3
    ALZHEIMER -.-|"associated"| STXBP3
    APOE -.-|"associated"| STXBP3
    SYNE2 -.-|"associated"| STXBP3
    SMARCB1 -.-|"associated"| STXBP3
    ULK2 -.-|"associated"| STXBP3
    TMEM59 -.-|"associated"| STXBP3
    SFPQ -.-|"associated"| STXBP3
    CCT4 -.-|"associated"| STXBP3
    CALB1 -.-|"associated"| STXBP3
    SORL1 -.-|"associated"| STXBP3
    IGF2R -.-|"associated"| STXBP3
    COPA -.-|"associated"| STXBP3
    style STXBP3 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (31)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
SORL1	associated_with	gene	0.60
APP	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
IDS	associated_with	gene	0.60
SYNE2	interacts_with	gene	0.60
TMEM59	interacts_with	gene	0.60
ULK2	interacts_with	gene	0.60
Igf	associated_with	protein	0.60
SSBP1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
SORL1	interacts_with	gene	0.50
SFPQ	interacts_with	protein	0.50
IGF2R	interacts_with	protein	0.50
SYNCRIP	interacts_with	concept	0.50
COPA	interacts_with	protein	0.50
ALZHEIMER	interacts_with	gene	0.50
ALZHEIMER'S	interacts_with	concept	0.50

Incoming (34)

Source	Relation	Type	Str
IDS	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
APP	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
SFPQ	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
COPA	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	associated_with	gene	0.60
APOE	interacts_with	gene	0.50
SYNE2	interacts_with	gene	0.50
SMARCB1	interacts_with	gene	0.50
TMEM59	interacts_with	gene	0.50
PRDX3	interacts_with	gene	0.50
SSBP1	interacts_with	gene	0.50
CALB1	interacts_with	gene	0.50
RNF14	interacts_with	gene	0.50
CCT4	interacts_with	gene	0.50
ULK2	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning STXBP3 in their description or question text

No additional research found