gene

IDS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IDS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

37Outgoing

23Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	IDS
Full Name	Iduronate Sulfatase
Chromosome	Xq28
Protein Type	Enzyme
Function	Iduronate sulfatase is a member of the sulfatase family of enzymes that share a common mechanism of post-translational modification.
Primary Expression	most tissues:
Amino Acids	550 aa
Exons	9
UniProt ID	P22304
NCBI Gene ID	3423
Ensembl ID	ENSG00000010373
OMIM	309900
GeneCards	IDS
Human Protein Atlas	IDS
Associated Diseases	Als, Alzheimer
Interactions	APOE, APP, CALB1, CCT4, COPA, IGF2R
KG Connections	60 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IDS — AlphaFold P22304 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IDS — Iduronate Sulfatase

gene · 2084 words

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Pathway Diagram

graph TD
    IDS["IDS"]
    Alzheimer["Alzheimer"]
    Als["Als"]
    SYNCRIP["SYNCRIP"]
    SSBP1["SSBP1"]
    PRDX3["PRDX3"]
    APP["APP"]
    ALZHEIMER["ALZHEIMER"]
    APOE["APOE"]
    SYNE2["SYNE2"]
    SMARCB1["SMARCB1"]
    ULK2["ULK2"]
    TMEM59["TMEM59"]
    SFPQ["SFPQ"]
    CCT4["CCT4"]
    CALB1["CALB1"]
    SORL1["SORL1"]
    IGF2R["IGF2R"]
    COPA["COPA"]
    STXBP3["STXBP3"]
    RNF14["RNF14"]
    IDS -.-|"associated"| Alzheimer
    IDS -.-|"associated"| Als
    IDS -.-|"associated"| SYNCRIP
    IDS -.-|"associated"| SSBP1
    IDS -.-|"associated"| PRDX3
    IDS -.-|"associated"| APP
    IDS -.-|"associated"| ALZHEIMER
    IDS -.-|"associated"| APOE
    IDS -.-|"associated"| SYNE2
    IDS -.-|"associated"| SMARCB1
    IDS -.-|"associated"| ULK2
    IDS -.-|"associated"| TMEM59
    IDS -.-|"associated"| SFPQ
    IDS -.-|"associated"| CCT4
    IDS -.-|"associated"| CALB1
    IDS -.-|"associated"| SORL1
    IDS -.-|"associated"| IGF2R
    IDS -.-|"associated"| COPA
    IDS -.-|"associated"| STXBP3
    IDS -.-|"associated"| RNF14
    style IDS fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (37)

Target	Relation	Type	Str
ALS	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
GENES	associated_with	gene	0.60
Igf	associated_with	protein	0.60
ALZHEIMER	associated_with	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
COPA	associated_with	gene	0.60
AND	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
IGF2R	interacts_with	gene	0.60
PRDX3	interacts_with	gene	0.60
RNF14	interacts_with	gene	0.60
SFPQ	interacts_with	gene	0.60
SMARCB1	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
SSBP1	interacts_with	gene	0.60
STXBP3	interacts_with	gene	0.60
SYNCRIP	interacts_with	gene	0.60
SYNE2	interacts_with	gene	0.60
TMEM59	interacts_with	gene	0.60
ULK2	interacts_with	gene	0.60

Incoming (23)

Source	Relation	Type	Str
COPA	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
APOE	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
APOE	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
CALB1	interacts_with	gene	0.60
CCT4	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	interacts_with	gene	0.60
SMARCB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
APP	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IDS in their description or question text

No additional research found