gene 1,377 words KG: TMEM59
Contents

TMEM59 Gene

🧬 Gene Info
Gene SymbolTMEM59
Full NameTransmembrane Protein 59
Chromosome9q34.3
Protein TypeType I transmembrane protein
Functionencodes a type I transmembrane protein with a lumenal N-terminus, a single transmembrane domain, and a short cytoplasmic C-terminal tail.
Subcellular LocalizationGolgi apparatus, Endoplasmic Reticulum
Pathwayspathway: #### Golgi Function
UniProt IDQ9H0M0
NCBI Gene ID9528
Ensembl IDENSG00000115616
OMIM610024
GeneCardsTMEM59
Human Protein AtlasTMEM59
Signal peptideN-terminal signal sequence for entry into the secretory pathway
Single transmembrane helixAnchors the protein in membrane compartments
Associated DiseasesAls, Alzheimer, Parkinson
InteractionsABP, ALZHEIMER, APOE, APP, ATG16L1, BACE1
KG Connections105 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (6)

APOE-Dependent Autophagy Restoration
Score: 0.88
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Microbial Inflammasome Priming Prevention
Score: 0.65
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Genes
index · KG edge: associated_with
CALB1 (Calbindin 1)
gene · KG edge: associated_with
cct4
gene · KG edge: associated_with
IDS — Iduronate Sulfatase
gene · KG edge: associated_with
PRDX3 — Peroxiredoxin 3
gene · KG edge: associated_with

Knowledge Graph (12 edges)

IDS associated_with TMEM59
SSBP1 associated_with TMEM59
APP associated_with TMEM59
ULK2 associated_with TMEM59
TMEM59 associated_with SFPQ
TMEM59 associated_with CCT4
TMEM59 associated_with CALB1
TMEM59 associated_with SORL1
TMEM59 associated_with IGF2R
TMEM59 associated_with STXBP3

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