gene

SSBP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SSBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

103Connections

0Hypotheses

0Analyses

50Outgoing

36Incoming

0Experiments

0Debates

Summary

SSBP1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, biomarker for, activates. Associated with Cancer, Glioblastoma, Ms. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SSBP1
Chromosome	14q12
Function	encodes a mitochondrial single-stranded DNA-binding protein essential for mitochondrial DNA (mtDNA) maintenance, replication, and repair.
Molecular Weight	17 kDa
Amino Acids	172 aa
Pathways	Apoptosis, Mitochondrial Function
GeneCards	SSBP1
Human Protein Atlas	SSBP1
N-terminal Domain (1-50 aa)	Contains mitochondrial targeting sequence (MTS) for import into mitochondria. The N-terminus also participates in tetramer formation.
DNA-Binding Domain (50-150 aa)	The central region contains the OB-fold (oligosaccharide/oligonucleotide-binding fold), which provides the ssDNA binding activity. This domain is highly conserved across species.
Associated Diseases	Als, Alzheimer, Cancer, Glioblastoma, Ms
Interactions	ALZHEIMER, AND, APOE, APOPTOSIS, APP, CALB1
KG Connections	103 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SSBP1 Gene

gene · 1253 words

→

SSBP1 Protein

protein · 956 words

→

Pathway Diagram

graph TD
    SSBP1["SSBP1"]
    mtDNA["mtDNA"]
    SSBP1 -->|"regulates"| mtDNA
    Ms{"Ms"}
    SSBP1 -->|"associated with"| Ms
    Cancer{"Cancer"}
    SSBP1 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    SSBP1 -->|"associated with"| Tumor
    Glioblastoma{"Glioblastoma"}
    SSBP1 -->|"associated with"| Glioblastoma
    SSBP1 -->|"activates"| Tumor
    RPA3["RPA3"]
    SSBP1 -->|"biomarker for"| RPA3
    CANCER["CANCER"]
    SSBP1 -->|"associated with"| CANCER
    GBM["GBM"]
    SSBP1 -->|"biomarker for"| GBM
    TUBB2A["TUBB2A"]
    SSBP1 -->|"biomarker for"| TUBB2A
    APOPTOSIS["APOPTOSIS"]
    SSBP1 -->|"activates"| APOPTOSIS
    MUL1["MUL1"]
    SSBP1 -->|"associated with"| MUL1
    HSF1["HSF1"]
    HSF1 -->|"inhibits"| SSBP1
    style SSBP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (67)

Target	Relation	Type	Str
mtDNA	regulates	DNA	0.70
ALS	associated_with	disease	0.65
Tumor	activates	disease	0.65
Glioblastoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	activates	disease	0.65
Cancer	associated_with	disease	0.65
Huntington	activates	disease	0.65
Ms	associated_with	disease	0.65
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Igf	associated_with	protein	0.60
Alzheimer's disease	interacts_with	disease	0.60
RPA3	biomarker_for	gene	0.60
GBM	biomarker_for	gene	0.60
TUBB2A	biomarker_for	gene	0.60
MUL1	associated_with	gene	0.60
HSF1	inhibits	gene	0.60
DRP1	activates	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
IDS	associated_with	gene	0.60
Apoptosis	activates	pathway	0.60
MITOCHONDRIA	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
HUNTINGTON	activates	gene	0.60
DNA	inhibits	gene	0.60
Mitochondrial Function	activates	pathway	0.60
AND	inhibits	gene	0.60
MITOCHONDRIAL DNA	inhibits	gene	0.60
HUNTINGTON'S DISEASE	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	associated_with	gene	0.60

Incoming (36)

Source	Relation	Type	Str
HSF1	inhibits	protein	0.70
SMARCB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
APP	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	associated_with	gene	0.60
COPA	interacts_with	gene	0.60
IDS	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
APOE	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
RNF14	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
APP	interacts_with	gene	0.60
CALB1	interacts_with	gene	0.60
CCT4	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
RNF14	interacts_with	gene	0.60
SFPQ	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
HUNTINGTON'S DISEASE	activates	gene	0.60
MITOCHONDRIAL DNA	inhibits	gene	0.60
AND	inhibits	gene	0.60
APOE	interacts_with	gene	0.50
SYNE2	interacts_with	gene	0.50
SMARCB1	interacts_with	gene	0.50
TMEM59	interacts_with	gene	0.50
PRDX3	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SSBP1 in their description or question text

No additional research found