gene

RNF14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RNF14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

89Connections

0Hypotheses

0Analyses

50Outgoing

34Incoming

0Experiments

0Debates

Summary

RNF14 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, implicated in. Associated with Aging, Als, Cancer. Connected to 11 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RNF14
Full Name	Ring Finger Protein 14
Chromosome	5q23.3
Protein Type	Ligase
Function	is a gene located on chromosome 5q23.
Primary Expression	Ubiquitously expressed; high expression in brain, testis, prostate
Amino Acids	511 aa
Exons	12
Pathways	ubiquitin-proteasome
UniProt ID	Q9Y2X9
NCBI Gene ID	9744
Ensembl ID	ENSG00000082630
OMIM	605423
GeneCards	RNF14
Human Protein Atlas	RNF14
Associated Diseases	Aging, Als, Alzheimer
Interactions	AGING, ALZHEIMER, APOE, APP, CALB1, CANCER
KG Connections	89 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RNF14 — AlphaFold Q9Y2X9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RNF14 — Ring Finger Protein 14

gene · 503 words

→

RNF149 Protein

protein · 685 words

→

Pathway Diagram

graph TD
    RNF14["RNF14"]
    Ms{"Ms"}
    RNF14 -->|"activates"| Ms
    Aging{"Aging"}
    RNF14 -->|"associated with"| Aging
    UBIQUITIN["UBIQUITIN"]
    RNF14 -->|"associated with"| UBIQUITIN
    neurodegeneration["neurodegeneration"]
    RNF14 -->|"implicated in"| neurodegeneration
    AND["AND"]
    AND -->|"associated with"| RNF14
    style RNF14 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (55)

Target	Relation	Type	Str
EEF1A	associated_with	entity	0.95
ALS	associated_with	disease	0.65
Aging	degrades	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Aging	associated_with	disease	0.65
App	degrades	protein	0.60
Alzheimer's disease	interacts_with	disease	0.60
SSBP1	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
IDS	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
APP	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
SMARCB1	interacts_with	gene	0.60
SSBP1	interacts_with	gene	0.60
SYNE2	interacts_with	gene	0.60
TMEM59	interacts_with	gene	0.60
Igf	associated_with	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
UBIQUITIN	activates	gene	0.60
TMEM59	associated_with	gene	0.60
UBIQUITIN	degrades	gene	0.60
APOE	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COPA	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	associated_with	gene	0.60
CANCER	activates	gene	0.60
UBIQUITIN	associated_with	gene	0.60
AGING	activates	gene	0.60
DNA	activates	gene	0.60
Proteins	associated_with	protein	0.50
COPA	interacts_with	protein	0.50
ALZHEIMER	interacts_with	gene	0.50
ALZHEIMER'S	interacts_with	concept	0.50
ULK2	interacts_with	gene	0.50
STXBP3	interacts_with	gene	0.50

Incoming (34)

Source	Relation	Type	Str
GCN1	interacts_with	entity	0.92
COPA	interacts_with	gene	0.60
COPA	associated_with	gene	0.60
IDS	associated_with	gene	0.60
SYNCRIP	associated_with	gene	0.60
SSBP1	associated_with	gene	0.60
PRDX3	associated_with	gene	0.60
APP	associated_with	gene	0.60
APOE	associated_with	gene	0.60
SYNE2	associated_with	gene	0.60
SMARCB1	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
TMEM59	associated_with	gene	0.60
SFPQ	associated_with	gene	0.60
CCT4	associated_with	gene	0.60
CALB1	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
STXBP3	associated_with	gene	0.60
UBIQUITIN	degrades	gene	0.60
APP	interacts_with	gene	0.60
CCT4	interacts_with	gene	0.60
IDS	interacts_with	gene	0.60
IGF2R	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
AND	degrades	gene	0.60
APOE	interacts_with	gene	0.50
SYNE2	interacts_with	gene	0.50
SMARCB1	interacts_with	gene	0.50
TMEM59	interacts_with	gene	0.50
PRDX3	interacts_with	gene	0.50
SSBP1	interacts_with	gene	0.50
CALB1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RNF14 in their description or question text

No additional research found