| Gene Symbol | STAT1 |
| Full Name | Signal Transducer and Activator of Transcription 1 |
| Aliases | Page for STAT1 Gene |
| Chromosome | 2q32.2 |
| Protein Type | Transcription Factor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 84 kDa |
| Pathways | cascade: ### Activation Mechanism, JAK-STAT signaling, JAK-STAT pathway |
| UniProt ID | P42224 |
| NCBI Gene ID | 6772 |
| Ensembl ID | ENSG00000115415 |
| GeneCards | STAT1 |
| Human Protein Atlas | STAT1 |
| Type I interferons (IFN-α/β) | Primary activators of STAT1 through the IFNAR receptor [7] |
| Type II interferon (IFN-γ) | Strong activator via the IFNGR receptor, driving MHC class I expression [8] |
| Associated Diseases | Als, Autoimmune, Depression, Infection, Inflammation |
| Known Drugs/Compounds | berberine, Curcumin, metformin, valproic acid |
| Interactions | ACE, AGING, AKT1, alpha-synuclein, ALZHEIMER, ALZHEIMER'S DISEASE |
| KG Connections | 863 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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