| Gene Symbol | SREBF2 |
| Full Name | Sterol Regulatory Element Binding Transcription Factor 2 |
| Aliases | SREBF2PROTEIN |
| Chromosome | 22 |
| Protein Type | Transcription Factor |
| Target Class | Transcription Factor |
| Function | SREBF2 plays a critical role in cholesterol metabolism, which is intimately connected to Alzheimer's disease pathogenesis through multiple mechanisms: |
| Mechanism of Action | Small molecule modulators of transcriptional activity or protein-protein interactions |
| Druggability | Undruggable (0.20) |
| Clinical Stage | Phase II |
| Pathways | Amyloid, Autophagy, Cholesterol, Cholesterol Metabolism, Mitophagy |
| UniProt ID | A0AA34QVX2 |
| Ensembl ID | ENSG00000198911 |
| GeneCards | SREBF2 |
| Human Protein Atlas | SREBF2 |
| Associated Diseases | Als, Alzheimer, neurodegeneration |
| Known Drugs/Compounds | rapamycin, RAPAMYCIN |
| Interactions | ABCA1, ACOX1, Adiponectin, ADIPOQ, AGING, AKT3 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | APOE4-associated inflammatory signaling amplifies |
| KG Connections | 568 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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