protein 1,247 words KG: SIRT5PROTEIN
Contents

SIRT5 Protein - Mitochondrial Desuccinylase

🔬 Protein Info
Gene SymbolSIRT5
Full NameSirtuin 5
AliasesPage for SIRT5 Protein
Chromosome6p23
Protein FamilySirtuin family (class I)
Functionis a member of the sirtuin family of NAD⁺-dependent protein deacylases that is primarily localized to mitochondria.
Molecular Weight34 kDa
Amino Acids310 aa
PathwaysGlutamine Metabolism, Glycolysis, Mitophagy, Oxidative Stress, Unfolded Protein Response
UniProt IDQ9NXE1
NCBI Gene ID83737
Ensembl IDENSG00000124587
OMIM604603
GeneCardsSIRT5
Human Protein AtlasSIRT5
Associated DiseasesAls, Alzheimer, cancer
Known Drugs/CompoundsMc3482, MC3482
InteractionsAGING, AKT2, ALZHEIMER, ALZHEIMER'S DISEASE, AND, App
KG Connections217 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Related Hypotheses (20)

Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.94
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (14)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (1)

Sirtuin Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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