protein

AKT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AKT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

97Connections

0Hypotheses

0Analyses

50Outgoing

15Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	AKT2
Full Name	AKT Serine/Threonine Kinase 2
Chromosome	19q13.2
Protein Type	Kinase
Function	is a crucial signaling molecule in the PI3K/AKT signaling pathway that plays essential roles in cell survival, metabolism, and neuronal function.
Primary Expression	Brain (widespread), Muscle, Liver, Adipose tissue
Exons	13
Pathways	Akt, Apoptosis, Autophagy, Immune Response, Mitophagy
UniProt ID	P31751
NCBI Gene ID	207
Ensembl ID	ENSG00000105221
OMIM	164731
GeneCards	AKT2
Human Protein Atlas	AKT2
Associated Diseases	Aging, Als, Atherosclerosis, Cancer, Cardiovascular
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, APP, APP/PS1
KG Connections	97 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AKT2 — AlphaFold P31751 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

AKT2 Gene

gene · 2958 words

→

AKT2 Protein

protein · 686 words

→

Pathway Diagram

graph TD
    AKT2["AKT2"] -->|"modulates"| Lysosomal_Synapse_Formation["Lysosomal Synapse Formation"]
    style Lysosomal_Synapse_Formation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"modulates"| Lysosomal_Synapses["Lysosomal Synapses"]
    style Lysosomal_Synapses fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"regulates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"regulates"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"associated"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"implicated in"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AKT2["AKT2"] -->|"implicated in"| Atherosclerosis["Atherosclerosis"]
    style Atherosclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AKT3["AKT3"] -->|"associated"| AKT2["AKT2"]
    style AKT3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    AKT["AKT"] -->|"associated"| AKT2["AKT2"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"regulates"| AKT2["AKT2"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MTOR["MTOR"] -->|"regulates"| AKT2["AKT2"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MIRNAS["MIRNAS"] -->|"regulates"| AKT2["AKT2"]
    style MIRNAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style AKT2 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (82)

Target	Relation	Type	Str
Lysosomal Synapse Formation	modulates	process	0.95
Glucose Metabolism	regulates	process	0.90
glucose uptake	promotes	process	0.88
Lysosomal Synapses	modulates	process	0.85
Hepatic Glycogen Synthesis	involved_in	process	0.85
Atherosclerosis	implicated_in	disease	0.65
Cancer	implicated_in	disease	0.65
Cardiovascular	implicated_in	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Diabetes	activates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Als	implicated_in	disease	0.65
Apoptosis	inhibits	pathway	0.60
Differentiation	inhibits	pathway	0.60
Insulin	activates	protein	0.60
DNA	activates	gene	0.60
ROS	activates	gene	0.60
mitochondrial function	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
AKT	associated_with	gene	0.60
AKT3	associated_with	gene	0.60
Pi3K/Akt	inhibits	pathway	0.60
VEGF	activates	gene	0.60
VEGF	regulates	gene	0.60
LC3	activates	gene	0.60
VEGF	inhibits	gene	0.60
VEGF	associated_with	gene	0.60
SIRT5	inhibits	gene	0.60
SIRT5	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
SIRT5	activates	gene	0.60
CFH	activates	gene	0.60
TFEB	targets	gene	0.60
APOPTOSIS	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
Mitophagy	regulates	pathway	0.60
Akt	regulates	pathway	0.60
CANCER	implicated_in	gene	0.60
AND	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
DIABETES MELLITUS	activates	gene	0.60
INS	regulates	gene	0.60
lipid metabolism	participates_in	pathway	0.60
SIRT5	targets	gene	0.60
AKT1	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
MUL1	regulates	gene	0.60
Phagocytosis	regulates	pathway	0.60

Incoming (15)

Source	Relation	Type	Str
IRS2	activates	gene	0.90
AKT1	associated_with	gene	0.60
CFH	activates	gene	0.60
APP	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
AGING	associated_with	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
AKT3	associated_with	gene	0.60
AKT	associated_with	gene	0.60
PI3K	regulates	gene	0.60
MTOR	regulates	gene	0.60
MIRNAS	regulates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
APP/PS1	activates	gene	0.60
ALZHEIMER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AKT2 in their description or question text

No additional research found