gene 1,200 words KG: SCD1
Contents

SCD1 Gene

🧬 Gene Info
Gene SymbolSCD1
Chromosome10q24.31
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmultiple cancers:
Molecular Weight60 kDa
Amino Acids360 aa
PathwaysAkt, Autophagy, Ferroptosis, Lipid Metabolism, Mtor
Ensembl IDENSG00000197294
GeneCardsSCD1
Human Protein AtlasSCD1
Enzyme typeMembrane-bound desaturase (EC 1.14.19.3)
LocationEndoplasmic reticulum membrane
SubstrateStearoyl-CoA (18:0), palmitoyl-CoA (16:0)
ProductOleoyl-CoA (18:1), palmitoleoyl-CoA (16:1)
Associated DiseasesALS, cancer, ferroptosis, Fibrosis
Known Drugs/CompoundsSalidroside
InteractionsACC, ACLY, ACSL4, AKT, ALOX15, AMPK
KG Connections261 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (9)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Senescence-Induced Lipid Peroxidation Spreading
Score: 0.73
Endothelial Glycocalyx Regeneration via Syndecan-1 Upregulat
Score: 0.71

Related Analyses (6)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (3)

Myricanol treatment in HFD-induced hyperlipidemic C57BL/6J m
validation · proposed · Score: 0.95
Myricanol-ACSL1 direct binding validation using CETSA and mo
exploratory · proposed · Score: 0.90
Multi-omics analysis of myricanol effects on gene expression
exploratory · proposed · Score: 0.88

See Also (12)

acc-chronic-pain
cell_type · KG edge: expressed_in
ATP P2X3 Receptor Neurons
cell · KG edge: inhibits
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: inhibits
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates

Knowledge Graph (12 edges)

FASN inhibits SCD1
BAX inhibits SCD1
ALOX15 inhibits SCD1
GSDMD inhibits SCD1
SCD1 inhibits HMGCR
SCD1 inhibits TNF
SCD1 inhibits MLKL
SCD1 inhibits ACSL4
MTOR inhibits SCD1
PTEN activates SCD1

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