concept

DIMETHYL FUMARATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DIMETHYL FUMARATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

120Connections

0Hypotheses

2Analyses

50Outgoing

9Incoming

0Experiments

2Debates

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💡 Concept Info

Name	DIMETHYL FUMARATE
Key Genes/Proteins	APP, CGAS
Related Diseases	ACETYLCHOLINE, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, AUTOPHAGY
Related Pathways	CGAS-STING PATHWAY

Pathway Diagram

graph TD
    DIMETHYL_FUMARATE["DIMETHYL FUMARATE"]
    DIMETHYL_FUMARATE -->|"activates"| NFE2L2["NFE2L2"]
    DIMETHYL_FUMARATE -->|"treats"| Cognitive_Impairment["Cognitive Impairment"]
    DIMETHYL_FUMARATE -->|"treats"| Cognitive_Dysfunction["Cognitive Dysfunction"]
    DIMETHYL_FUMARATE -->|"modulates"| ASTROCYTES["ASTROCYTES"]
    DIMETHYL_FUMARATE -->|"inhibits"| STAT3["STAT3"]
    DIMETHYL_FUMARATE -->|"treats"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    DIMETHYL_FUMARATE -->|"activates"| NRF2_PATHWAY["NRF2 PATHWAY"]
    DIMETHYL_FUMARATE -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    ASTROCYTES -->|"activates"| DIMETHYL_FUMARATE
    APP["APP"] -->|"activates"| DIMETHYL_FUMARATE

Outgoing (111)

Target	Relation	Type	Str
NFE2L2	activates	gene	0.90
NRF2	activates	protein	0.90
Cognitive Impairment	treats	phenotype	0.88
Cognitive Dysfunction	treats	phenotype	0.88
STAT3	inhibits	gene	0.85
ASTROCYTES	modulates	cell_type	0.85
ALZHEIMER'S DISEASE	treats	disease	0.82
LC3	activates	gene	0.70
PINK1	activates	gene	0.70
Ferroptosis	protects_against	mechanism	0.70
NRF2 PATHWAY	activates	pathway	0.65
MULTIPLE SCLEROSIS	activates	disease	0.65
NRF2	produces	gene	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
NRF2	regulates	gene	0.65
AUTOPHAGY	treats	phenotype	0.65
AUTOPHAGY	regulates	phenotype	0.65
MULTIPLE SCLEROSIS	interacts_with	disease	0.65
INFLAMMATION	treats	phenotype	0.65
MULTIPLE SCLEROSIS	treats	disease	0.65
CGAS-STING PATHWAY	activates	pathway	0.65
NECROPTOSIS	inhibits	phenotype	0.65
RNA	treats	gene	0.60
GAPDH	activates	gene	0.60
PTEN	activates	gene	0.60
NDP52	activates	gene	0.60
OPTN	activates	gene	0.60
CASP3	activates	gene	0.60
mitochondrial dynamics	modulates	pathway	0.60
HTT	activates	gene	0.60
NBR1	activates	gene	0.60
BCL2	activates	gene	0.60
PRKN	activates	gene	0.60
CALCOCO2	activates	gene	0.60
neuroinflammation	treats	disease	0.60
C3	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
C3	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
HTT	regulates	gene	0.60
LC3	regulates	gene	0.60
NBR1	regulates	gene	0.60
BCL2	regulates	gene	0.60
PRKN	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60
GAPDH	regulates	gene	0.60
PTEN	regulates	gene	0.60
PINK1	regulates	gene	0.60
NDP52	regulates	gene	0.60
OPTN	regulates	gene	0.60

Incoming (9)

Source	Relation	Type	Str
CGAS-STING PATHWAY	associated_with	pathway	0.50
ALZHEIMER	associated_with	disease	0.45
APP	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.35
ASTROCYTES	activates	cell_type	0.35
APP	activates	gene	0.35