Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DAPAGLIFLOZIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | DAPAGLIFLOZIN |
| Key Genes/Proteins | AMYLOID, TAU |
| Related Diseases | APOPTOSIS, ATP, DEMENTIA, INFLAMMATION, NEUROINFLAMMATION |
graph TD
DAPAGLIFLOZIN[DAPAGLIFLOZIN]
DAPAGLIFLOZIN -->|downregulates| MTOR[MTOR]
DAPAGLIFLOZIN -->|treats| Ptz_Induced_Kindling[Ptz-Induced Kindling]
DAPAGLIFLOZIN -.protects against.-> PARKINSON_S_DISEASE[PARKINSON'S DISEASE]
DAPAGLIFLOZIN -->|interacts| OXIDATIVE_STRESS[OXIDATIVE STRESS]| Target | Relation | Type | Str |
|---|---|---|---|
| MTOR | downregulates | gene | 0.80 |
| Ptz-Induced Kindling | treats | disease | 0.80 |
| OXIDATIVE STRESS | interacts_with | phenotype | 0.65 |
| PARKINSON'S DISEASE | protects_against | disease | 0.65 |
| OXIDATIVE STRESS | targets | phenotype | 0.65 |
| AMYLOID | associated_with | protein | 0.45 |
| SEMAGLUTIDE | associated_with | drug | 0.45 |
| ATP | associated_with | phenotype | 0.45 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| APOPTOSIS | associated_with | phenotype | 0.45 |
| DEMENTIA | associated_with | disease | 0.45 |
| SUPEROXIDE | associated_with | phenotype | 0.45 |
| TAU | associated_with | protein | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| EMPAGLIFLOZIN | associated_with | drug | 0.45 |
| PARKINSON'S DISEASE | associated_with | disease | 0.45 |
| OXIDATIVE STRESS | associated_with | phenotype | 0.45 |
| TAU PHOSPHORYLATION | associated_with | phenotype | 0.45 |
| NEUROINFLAMMATION | associated_with | phenotype | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DAPAGLIFLOZIN in their description or question text
No additional research found