Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about USP25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | USP25 |
| Key Genes/Proteins | BRCC3, CYLD, EP300, FASN, IRS2, OPTN |
| Related Diseases | Blood-Brain Barrier Dysfunction, neurodegeneration, Parkinson's disease |
| Related Pathways | autophagy pathway, blood-brain barrier |
graph TD
USP25[USP25]
USP25 -->|interacts| OPTN[OPTN]
USP25 -->|risk_factor_for| Parkinson_s_disease[Parkinson's disease]
USP25 -->|inhibits| mitophagy[mitophagy]
USP25 -->|implicated in| neuroinflammation[neuroinflammation]
USP25 -->|inhibits| neurodegeneration[neurodegeneration]
USP25 -->|participates in| blood_brain_barrier[blood-brain barrier]
USP25 -->|expressed in| stem_cells[stem cells]
USP25 -->|participates in| ubiquitin_proteasome[ubiquitin-proteasome]
USP25 -->|participates in| autophagy_pathway[autophagy pathway]
BRCC3[BRCC3] -->|interacts| USP25
CYLD[CYLD] -->|interacts| USP25
USP13[USP13] -->|interacts| USP25
USP14[USP14] -->|interacts| USP25
EP300[EP300] -->|causes| USP25
FASN[FASN] -->|causes| USP25
IRS2[IRS2] -->|causes| USP25
PIK3CA[PIK3CA] -->|causes| USP25
benchmark_ot_ad_answer_key_USP[benchmark_ot_ad_answer_key:USP25] -->|data_in| USP25| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:USP25 | data_in | dataset_row | 0.00 |
| OPTN | interacts_with | protein | 0.95 |
| Parkinson's disease | risk_factor_for | disease | 0.95 |
| mitophagy | inhibits | process | 0.90 |
| Parkinson's disease | therapeutic_target | disease | 0.90 |
| Blood-Brain Barrier Dysfunction | associated_with | phenotype | 0.85 |
| neuroinflammation | implicated_in | process | 0.70 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| blood-brain barrier | participates_in | pathway | 0.60 |
| neurodegeneration | inhibits | disease | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning USP25 in their description or question text
No additional research found